Bacterial DNA findings in ruptured and unruptured intracranial aneurysms

Acta Odontologica Scandinavica
Mikko J PyysaloJuha E Öhman

Abstract

Chronic inflammation has earlier been detected in ruptured intracranial aneurysms. A previous study detected both dental bacterial DNA and bacterial-driven inflammation in ruptured intracranial aneurysm walls. The aim of this study was to compare the presence of oral and pharyngeal bacterial DNA in ruptured and unruptured intracranial aneurysms. The hypothesis was that oral bacterial DNA findings would be more common and the amount of bacterial DNA would be higher in ruptured aneurysm walls than in unruptured aneurysm walls. A total of 70 ruptured (n = 42) and unruptured (n = 28) intracranial aneurysm specimens were obtained perioperatively in aneurysm clipping operations. Aneurysmal sac tissue was analysed using a real-time quantitative polymerase chain reaction to detect bacterial DNA from several oral species. Both histologically non-atherosclerotic healthy vessel wall obtained from cardiac by-pass operations (LITA) and arterial blood samples obtained from each aneurysm patient were used as control samples. Bacterial DNA was detected in 49/70 (70%) of the specimens. A total of 29/42 (69%) of the ruptured and 20/28 (71%) of the unruptured aneurysm samples contained bacterial DNA of oral origin. Both ruptured and unruptured an...Continue Reading

References

Nov 1, 1980·Journal of Neurosurgery·J G FrazeeJ Winter
Jan 25, 2000·Circulation·M RoivainenM Mänttäri
Jul 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J F BlanchardR C Brunham
Feb 24, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·M Gattone
Jan 11, 2005·European Journal of Clinical Investigation·J LehtiniemiS T Nikkari
Jul 15, 2005·Annals of Periodontology·George HajishengallisRobert J Genco
Sep 15, 2005·Clinical Medicine & Research·Nao SuzukiYoshio Nakano
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Valery L FeiginCraig S Anderson
Oct 28, 2006·The Lancet Infectious Diseases·Philip J PetersJeffrey L Lennox
May 2, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·N K de RooijG J E Rinkel
Mar 27, 2009·Neurocritical Care·Sudheeran Kannoth, Sanjeev V Thomas
Oct 20, 2009·Neurosurgical Review·Andrew F DucruetE Sander Connolly
Jan 30, 2010·Methods : a Companion to Methods in Enzymology·Ales TichopadMichael W Pfaffl
Oct 5, 2010·Case Reports in Medicine·Isabel KuoNerses Sanossian
Nov 19, 2011·Journal of Clinical Periodontology·Kåre BuhlinPirkko J Pussinen
Feb 19, 2013·Circulation·Tanja PessiJussi Mikkelsson
May 3, 2013·Journal of Clinical Periodontology·Maurizio S TonettiUNKNOWN Working group 1 of the joint EFP/AAP workshop
Jun 14, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Mikko J PyysaloJuha E Öhman
May 21, 2015·Journal of Dental Research·J M LiljestrandP J Pussinen

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Citations

Sep 8, 2018·Neurologia i neurochirurgia polska·Wojciech GruszkaJan Baron
Jan 10, 2019·Hypertension·Fumiaki ShikataTomoki Hashimoto
May 24, 2019·Journal of the American Heart Association·Olli PatrakkaMika Martiskainen
Mar 29, 2019·The Journal of Craniofacial Surgery·Qiu XingangLiu Qian
Jul 14, 2019·The Journal of Craniofacial Surgery·Qiu XingangLiu Qian
Jul 28, 2020·CNS & Neurological Disorders Drug Targets·Qin HuangJian Xia
Jun 20, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Joona HallikainenJuhana Frösen
Aug 20, 2021·Odontology·Steeve BregaintAnne Jolivet-Gougeon
Mar 6, 2019·Journal of Neurosurgery·Rabih AboukaisJean-Paul Lejeune
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