Bacterial DNA ligases

Molecular Microbiology
A WilkinsonRichard P Bowater

Abstract

DNA ligases join breaks in the phosphodiester backbone of DNA molecules and are used in many essential reactions within the cell. All DNA ligases follow the same reaction mechanism, but they may use either ATP or NAD+ as a cofactor. All Bacteria (eubacteria) contain NAD+-dependent DNA ligases, and the uniqueness of these enzymes to Bacteria makes them an attractive target for novel antibiotics. In addition to their NAD+-dependent enzymes, some Bacteria contain genes for putative ATP-dependent DNA ligases. The requirement for these different isozymes in Bacteria is unknown, but may be related to their utilization in different aspects of DNA metabolism. The putative ATP-dependent DNA ligases found in Bacteria are most closely related to proteins from Archaea and viruses. Phylogenetic analysis suggests that all NAD+-dependent DNA ligases are closely related, but the ATP-dependent enzymes have been acquired by Bacterial genomes on a number of separate occasions.

References

Jan 19, 2008·Neurotoxicity Research·Ka Ka TingGilles Guillemin
Dec 1, 2006·Extremophiles : Life Under Extreme Conditions·Brian R JacksonRichard P Bowater
Jun 8, 2013·World Journal of Microbiology & Biotechnology·Neda SetayeshZargham Sepehrizadeh
Dec 24, 2003·Trends in Biotechnology·Weiguo Cao
Mar 22, 2003·Current Opinion in Cell Biology·Su-Ju Lin, Leonard Guarente
Aug 31, 2004·BMC Evolutionary Biology·Marinalva Martins-PinheiroCarlos F M Menck
Mar 7, 2006·PLoS Genetics·Richard P Bowater, Aidan J Doherty
Jan 29, 2002·Nucleic Acids Research·V Sriskanda, Stewart Shuman
Jan 21, 2014·Analytical and Bioanalytical Chemistry·Zhijuan CaoJianzhong Lu
Jan 9, 2014·Genome Biology and Evolution·Kasie RaymannSimonetta Gribaldo
Mar 4, 2014·Protein Expression and Purification·Adele Williamson, Hege Pedersen
May 14, 2014·Analytical and Bioanalytical Chemistry·Eva StejskalováMiroslav Fojta
Oct 4, 2005·Journal of Bacteriology·Niroshika Keppetipola, Stewart Shuman
Dec 20, 2005·Nucleic Acids Research·Sandeep Kumar SrivastavaRavishankar Ramachandran
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Hirokazu NishidaKosuke Morikawa
Apr 6, 2006·Journal of Bacteriology·Svetlana Y GerdesAndrei L Osterman
May 10, 2007·Nucleic Acids Research·Hui Zhu, Stewart Shuman
Jun 6, 2007·Antimicrobial Agents and Chemotherapy·Malgorzata Korycka-MachalaJarosław Dziadek
Feb 16, 2008·Nucleic Acids Research·Dmitry A RodionovNadia Raffaelli
Feb 16, 2008·Nucleic Acids Research·Dmitry A RodionovAndrei L Osterman
Jun 4, 2008·Annual Review of Biochemistry·Tom Ellenberger, Alan E Tomkinson
Jun 9, 2009·Applied and Environmental Microbiology·I-Chien ChenWen-Hwei Hsu
Jun 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sanna Koskiniemi, Dan I Andersson
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Francesca GazzanigaCharles Brenner
Nov 20, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Seungil HanMatt Griffor
Dec 30, 2010·Antimicrobial Agents and Chemotherapy·Scott D MillsSuzanne S Stokes
Feb 22, 2002·European Journal of Biochemistry·Masaru NakataniTadayuki Imanaka
May 18, 2007·Annual Review of Microbiology·Robert S PitcherAidan J Doherty
Oct 1, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shengjun WangLihe Zhang
Mar 31, 2012·Expert Opinion on Drug Discovery·Gautam Sanyal, Peter Doig
Nov 13, 2014·Critical Reviews in Biochemistry and Molecular Biology·Jeremy W SchroederLyle A Simmons
Jun 24, 2008·Critical Reviews in Biochemistry and Molecular Biology·Melanie BlasiusUlrich Hübscher
Feb 26, 2016·Metabolic Engineering·Kohsuke HondaHisao Ohtake
Nov 14, 2012·Protein Expression and Purification·You WangXi-Peng Liu
Apr 26, 2011·Tuberculosis·Ashish AroraMamannamana Vijayan
May 31, 2012·Science China. Life Sciences·Yoshizumi Ishino, Sonoko Ishino

Citations

Nov 29, 1974·Science·I R Lehman
Aug 1, 1995·Molecular Microbiology·Stewart Shuman, B Schwer
Apr 1, 1997·Nucleic Acids Research·C Cheng, Stewart Shuman
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alan E Tomkinson, D S Levin
Jan 8, 1999·Journal of Molecular Biology·D J Timson, D B Wigley
Jun 16, 1999·Structure·M R SingletonD B Wigley
Aug 18, 2000·Mutation Research·D J TimsonD B Wigley
Aug 18, 2000·Mutation Research·T HuytonP S Freemont
Oct 29, 2000·Journal of Bacteriology·Masaru NakataniTadayuki Imanaka
Nov 1, 2000·Nucleic Acids Research·A J Doherty, S W Suh
Nov 30, 2000·Nucleic Acids Research·M A Petit, S D Ehrlich
Feb 24, 2001·Nature·N T PernaF R Blattner
Mar 10, 2001·Nature·S T ColeB G Barrell

Related Concepts

Enzymes, antithrombotic
Antibiotic throat preparations
Antifungal Antibiotics, Topical
Homologous Sequences, Amino Acid
Archaea
NADH
Antibiotics, Gynecological
Enzymes for Treatment of Wounds and Ulcers
T4 DNA Ligase
Antibiotics for systemic use

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.