Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions

The Journal of Infectious Diseases
Paul B KeiserT B Nutman

Abstract

Treatment of onchocerciasis with diethylcarbamazine (DEC) or ivermectin is associated with a posttreatment reaction characterized by fever, tachycardia, hypotension, lymphadenopathy, and pruritus. To investigate the role of the Wolbachia bacterial endosymbiont of Onchocerca volvulus in these reactions, serum samples collected before and after treatment with either anthelmintic were assessed for evidence of Wolbachia DNA. By use of real-time quantitative polymerase chain reaction, Wolbachia DNA was detected in both groups-with significantly higher levels in those who received DEC (P <.0001). In the ivermectin group, there was a significant correlation between levels of bacterial DNA and serum tumor necrosis factor-alpha (P =.013). Peak DNA levels correlated with reaction scores (P =.048). Significant correlations were also seen between Wolbachia DNA and the antibacterial peptides calprotectin (P =.021) and calgranulin B (P <.0001). These findings support a role for Wolbachia products in mediating the inflammatory responses seen following treatment of onchocerciasis and suggest new targets for modulating these reactions.

Citations

Jan 12, 2007·Veterinary Research Communications·F SimónC Genchi
Feb 21, 2002·Current Infectious Disease Reports·Paul B. Keiser, Thomas B. Nutman
Apr 7, 2005·Molecular and Biochemical Parasitology·Tarig B HigaziThomas R Unnasch
Jun 10, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joseph KamgnoMichel Boussinesq
May 12, 2005·Veterinary Parasitology·L KramerC Bazzocchi
Mar 24, 2004·Nature Reviews. Microbiology·J K Lazdins-HeldsB Boakye
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph D TurnerAchim Hoerauf
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick J Lammie
Apr 29, 2006·The Pediatric Infectious Disease Journal·Bradley G Olson, Joseph B Domachowske
Aug 23, 2003·Infection and Immunity·George A PunkosdyPatrick J Lammie
Jan 25, 2003·BMJ : British Medical Journal·Achim HoeraufEric Pearlman
Jun 13, 2003·Filaria Journal·Dietrich W BüttnerPeter Fischer
Jun 21, 2003·Filaria Journal·Helen F McGarryMark J Taylor
Jan 22, 2009·Parasites & Vectors·Mark J TaylorOhene Adjei
Apr 18, 2012·PLoS Neglected Tropical Diseases·Kathrin ArndtsAchim Hoerauf
Dec 5, 2012·PLoS Neglected Tropical Diseases·Jan-Hendrik SchroederRachel A Lawrence
Jan 9, 2009·The Journal of Parasitology·G GrandiF Simon
Jun 5, 2014·Parasitology Research·Amira Taman, Manar Azab
Dec 25, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A Chosidow, D Gendrel
Jul 16, 2003·Annals of the New York Academy of Sciences·Mark J Taylor
Oct 29, 2003·Trends in Parasitology·David H MolyneuxMark J Taylor
Jun 10, 2014·Parasite Immunology·F TamarozziM J Taylor
Jun 10, 2008·Molecular and Biochemical Parasitology·Paul B KeiserThomas B Nutman
Sep 26, 2016·Trends in Parasitology·Benjamin L Makepeace, Vincent N Tanya
Oct 19, 2016·Scientific Reports·Francesca TamarozziMark J Taylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.