Bacterial endotoxin induces STAT3 activation in the mouse brain

Brain Research
Toru HosoiYasuyuki Nomura

Abstract

In the present study, we investigated regulatory mechanisms of bacterial endotoxin-induced STAT3 activation in the brain. Intraperitoneal injection of lipopolysaccharide (LPS) dose-dependently (0.5-5000 microg/kg) induced STAT3 phosphorylation in the hypothalamus. LPS-induced STAT3 phosphorylation was peaked at 2-4 h and declined there after. Moreover, intracerebroventricular injection of LPS induced STAT3 phosphorylation in the cortex and the hippocampus, indicating that central as well as peripheral LPS can act in the brain to induce STAT3 activation. Glucocorticoids are known to play a physiological role in the feedback inhibition of immune/inflammatory responses in the endocrine system. Interestingly, we observed no effect of dexamethasone on LPS-induced STAT3 phosphorylation in the hypothalamus. These findings point to the important role of STAT3 in the neuroimmune interaction of inflammation in the brain.

References

Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L ShapiroC A Dinarello
May 1, 1996·The Journal of Clinical Investigation·C GrunfeldK R Feingold
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Jan 31, 1998·The Journal of Clinical Investigation·J Licinio, M L Wong
Jun 30, 2000·Biochemical and Biophysical Research Communications·T HosoiY Nomura
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P D LambertS J Wiegand
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru HosoiYasuyuki Nomura
Feb 20, 2002·Trends in Neurosciences·Jan Pieter KonsmanRobert Dantzer
Apr 26, 2002·Trends in Microbiology·Xavier NassifPierre-Olivier Couraud
Aug 24, 2002·Endocrinology·Toru HosoiYasuyuki Nomura
Aug 2, 2003·The Journal of Biological Chemistry·Shizuo Akira
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Toru HosoiYasuyuki Nomura

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Citations

Mar 8, 2014·Brain, Behavior, and Immunity·Silvia AlboniFabio Tascedda
Mar 26, 2005·Current Opinion in Neurology·Henrik Hagberg, Carina Mallard
Jan 15, 2010·International Journal of Radiation Biology·Yutong HaoZhengping Yu
Sep 23, 2008·The Journal of Comparative Neurology·Christoph RummelGiamal N Luheshi
Dec 14, 2004·Journal of Neuroimmunology·Keisuke SakoYasuyuki Nomura
Aug 7, 2013·Molecular and Cellular Endocrinology·G A SantosM A Torsoni
Jul 20, 2007·Molecular Endocrinology·Johanna L BarclayJon D Curlewis
Jul 1, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph RummelGiamal N Luheshi
Dec 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yosuke YamawakiKoichiro Ozawa
Sep 11, 2014·Frontiers in Neural Circuits·Emily K StephensAllan T Gulledge
Feb 18, 2011·Endocrinology·Janette H QuennellGreg M Anderson
Jul 9, 2016·Neuroreport·Toru HosoiKoichiro Ozawa
Apr 21, 2021·Journal of Neuroinflammation·Luis A Rojas-ColónWanda I Vélez-Torres

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