PMID: 6985676Jan 4, 1980Paper

Bacterial endotoxin (lipopolysaccharide) as a cause of erythema multiforme

JAMA : the Journal of the American Medical Association
W B Shelley

Abstract

The classic iris lesions in a patient with erythema multiforme bullosum were reproduced grossly as well as microscopically by the intradermal injection of a variety of heat-killed, Gram-negative bacteria, as well as their common endotoxin, lipopolysaccharide W. In vitro exposure of the patient's blood to these antigens induced specific fibrin microclots characteristic of a hypersensitivity state. It is possible that some cases of erythema multiforme associated with a variety of respiratory, gastrointestinal, or urinary tract infections may represent a single specific delayed sensitivity reaction to the bacterial endotoxin, lipopolysaccharide.

Citations

Jul 1, 1990·Ophthalmology·B J Mondino
Apr 1, 1983·Journal of the American Academy of Dermatology·M DuvicE Ciftan
Nov 1, 1987·Journal of Pediatric Surgery·C G HowellR A Parrish
Oct 1, 1981·The Journal of Dermatology·W B Shelley
Feb 1, 1995·Acta Paediatrica Japonica; Overseas Edition·A SaitohK Nishimura

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