Jan 26, 2018

Bacterial genome-wide association study: methodologies and applications

Yi chuan = Hereditas
Chao YangYujun Cui

Abstract

With the development of genome sequencing and the accumulation of whole genome sequences, genome-wide association study (GWAS) has achieved remarkable advances in understanding of human complex disease, and tens of thousands of disease risk factors have been found. Meanwhile, GWAS provides a new tool for exploring the genetic mechanism of bacterial phenotypes. Since the publication of the first bacterial GWAS (BGWAS) work in 2013, there have been more than 10 reports, which reveal the genetic basis of host adaption, drug resistance and virulence, etc. These findings greatly enhance our understanding on genetics, evolution and spread of bacteria. In this review, we summarize the current methodologies, applications and problems of BGWAS and highlight its potential in future research, which aims to provide helps for the applications of BGWAS in the field of microbiology.

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Mentioned in this Paper

Genome-Wide Association Study
TNS3
Research
Genome
Acclimatization
Adaptation
Virulence
Toxic Epidermal Necrolysis
Drug Resistance
Genome Sequencing

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