PMID: 8606194Apr 1, 1996Paper

Bacterial glutathione: a sacrificial defense against chlorine compounds

Journal of Bacteriology
J A ChesneyJ R Mahoney

Abstract

Aerobic organisms possess a number of often overlapping and well-characterized defenses against common oxidants such as superoxide and hydrogen peroxide. However, much less is known of mechanisms of defense against halogens such as chlorine compounds. Although chlorine-based oxidants may oxidize a number of cellular components, sulfhydrl groups are particularly reactive. We have, therefore, assessed the importance of intracellular glutathione in protection of Escherichia coli cells against hydrogen peroxide, hypochlorous acid, and chloramines. Employing a glutathione-deficient E. coli strain (JTG10) and an otherwise isogenic glutathione-sufficient E. coli strain (AB1157), we find that glutathione-deficient organisms are approximately twice as sensitive to killing by both hydrogen peroxide and chlorine compounds. However, the mode of protection by glutathione in these two cases appears to differ: exogenous glutathione added to glutathione-deficient E. coli in amounts equal to those which would be present in a similar suspension of the wild-type bacteria fully restored resistance of glutathione-deficient bacteria to chlorine-based oxidants but did not change resistance to hydrogen peroxide. Furthermore, in protection against chlo...Continue Reading

References

Mar 1, 1978·Journal of Bacteriology·R C FaheyM B Worsham
Aug 1, 1992·Archives of Biochemistry and Biophysics·C C WinterbournF A Kuypers
Aug 11, 1991·Analytical Biochemistry·J A ChesneyJ W Eaton
Mar 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C Bernofsky
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H RosenD R VanDevanter
May 1, 1990·Applied and Environmental Microbiology·D G KorichC R Sterling
Nov 1, 1986·Journal of Bacteriology·J T Greenberg, B Demple
Jun 16, 1971·Biochimica Et Biophysica Acta·J M ZgliczyńskiW Ostrowski
Oct 1, 1984·The Journal of Clinical Investigation·S T TestS J Weiss
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J M AlbrichJ K Hurst
Sep 1, 1982·The Journal of Clinical Investigation·S J WeissM Wei
Feb 24, 1983·Nature·C S FooteR I Lehrer
Sep 1, 1993·Molecular Microbiology·G P FergusonI R Booth
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN

❮ Previous
Next ❯

Citations

Jun 19, 2013·Annual Review of Microbiology·Michael J GrayUrsula Jakob
Apr 1, 2015·Canadian Journal of Microbiology·Nisanart CharoenlapPaiboon Vattanaviboon
Aug 21, 2001·Journal of Food Protection·B LeverentzA Sulakvelidze
Mar 24, 2000·Redox Report : Communications in Free Radical Research·H TweeddaleT Ferenci
Dec 14, 2011·Biotechnology Letters·Ji Eun KimNam Soo Han
Jul 11, 2012·Molecular BioSystems·Antonella AlbinoEmmanuele De Vendittis
Nov 14, 2013·PloS One·Zoltán NoszticziusJános Szegedi
Jan 1, 1999·Bioscience, Biotechnology, and Biochemistry·K SuginakaH Shibata
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·L OchoaF L Minnear
Dec 13, 2005·Biochemistry. Biokhimii︠a︡·G V Smirnova, O N Oktyabrsky
Jul 26, 2005·The Journal of Biological Chemistry·Marc S PittmanRobert K Poole
Jul 19, 2005·Archives of Microbiology·Yancheng LiuShaoyi Huang
Jan 24, 2016·Applied and Environmental Microbiology·Xi Jia Ooi, Kai Soo Tan
Jul 23, 2013·Journal of Dental Research·X ZhengX Xu
Feb 1, 1997·Redox Report : Communications in Free Radical Research·A J Kettle, C C Winterbourn
Jul 25, 2019·Journal of Bacteriology·Elizabeth A WalkerBlythe E Janowiak
Mar 23, 2005·Canadian Journal of Microbiology·Etelvina Maria de Almeida Paula FigueiraSofia Isabel Almeida Pereira
Jun 15, 2006·Antioxidants & Redox Signaling·Lluis MasipGeorge Georgiou
Sep 9, 2015·Applied Microbiology and Biotechnology·Da-Hui WangBin Qi
Mar 30, 2010·Protoplasma·Bernd ZechmannHrvoje Fulgosi
May 20, 2015·MicrobiologyOpen·Zhong Fang, Patricia C Dos Santos
Jan 20, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jason Ching-Yao LinChun-Hung Lin
Feb 20, 2003·Journal of Bacteriology·Bjorn VergauwenJozef J Van Beeumen
Jan 11, 2007·Antimicrobial Agents and Chemotherapy·Manish GoswamiNarendra Jawali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.