Bacterial 'Grounded' Prophages: Hotspots for Genetic Renovation and Innovation

Frontiers in Genetics
Bhaskar Chandra Mohan Ramisetty, Pavithra Anantharaman Sudhakari

Abstract

Bacterial genomes are highly plastic allowing the generation of variants through mutations and acquisition of genetic information. The fittest variants are then selected by the econiche thereby allowing the bacterial adaptation and colonization of the habitat. Larger genomes, however, may impose metabolic burden and hence bacterial genomes are optimized by the loss of frivolous genetic information. The activity of temperate bacteriophages has acute consequences on the bacterial population as well as the bacterial genome through lytic and lysogenic cycles. Lysogeny is a selective advantage as the prophage provides immunity to the lysogen against secondary phage attack. Since the non-lysogens are eliminated by the lytic phages, lysogens multiply and colonize the habitat. Nevertheless, all lysogens have an imminent risk of lytic cycle activation and cell lysis. However, a mutation in the attachment sites or in the genes that encode the specific recombinase responsible for prophage excision could result in 'grounding' of the prophage. Since the lysogens with grounded prophage are immune to respective phage infection as well as dodge the induction of lytic cycle, we hypothesize that the selection of these mutant lysogens is favored ...Continue Reading

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Citations

Nov 5, 2019·Applied and Environmental Microbiology·Jee-Hwan OhJan-Peter van Pijkeren
Aug 19, 2020·Viruses·Jonathan ColombetTélesphore Sime-Ngando
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Methods Mentioned

BETA
environmental stress
genetic modifications

Software Mentioned

BLASTn
PhageWeb
VirSorter
econiche
BLAST

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