bacterial infection drives the expression dynamics of microRNAs and their isomiRs

PLoS Genetics
Katherine J SiddleLluís Quintana-Murci

Abstract

The optimal coordination of the transcriptional response of host cells to infection is essential for establishing appropriate immunological outcomes. In this context, the role of microRNAs (miRNAs)--important epigenetic regulators of gene expression--in regulating mammalian immune systems is increasingly well recognised. However, the expression dynamics of miRNAs, and that of their isoforms, in response to infection remains largely unexplored. Here, we characterized the genome-wide miRNA transcriptional responses of human dendritic cells, over time, to various mycobacteria differing in their virulence as well as to other bacteria outside the genus Mycobacterium, using small RNA-sequencing. We detected the presence of a core temporal response to infection, shared across bacteria, comprising 49 miRNAs, highlighting a set of miRNAs that may play an essential role in the regulation of basic cellular responses to stress. Despite such broadly shared expression dynamics, we identified specific elements of variation in the miRNA response to infection across bacteria, including a virulence-dependent induction of the miR-132/212 family in response to mycobacterial infections. We also found that infection has a strong impact on both the r...Continue Reading

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Citations

Feb 9, 2016·Expert Review of Molecular Diagnostics·Margaret Dellett, David Arthur Simpson
Oct 6, 2017·Nucleic Acids Research·Feng YuCameron P Bracken
Apr 25, 2018·The FEBS Journal·Charlotte NejadMichael P Gantier
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Jun 9, 2021·The Indian Journal of Tuberculosis·Priyanka Mehta

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Methods Mentioned

BETA
RNA-seq
ChIP-seq
FCS
chip
CLIP-seq
PCR
PCA
sRNA-seq
Illumina sequencing

Software Mentioned

Python
miRDeep
fastq
TargetScan
AMOVA
R package glmmADMB
BEDTools
DESeq
Bioconductor package
R

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