Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds--an in vitro efficacy study

Scientific Reports
Rui MaLing Qin

Abstract

Bone infections are common in trauma-induced open fractures with bone defects. Therefore, developing anti-infection scaffolds for repairing bone defects is desirable. This study develoepd novel Mg-based porous composite scaffolds with a basal matrix composed of poly(lactic-co-glycolicacid) (PLGA) and tricalcium phosphate (TCP). A unique low-temperature rapid prototyping technology was used to fabricate the scaffolds, including PLGA/TCP (PT), PLGA/TCP/5%Mg (PT5M), PLGA/TCP/10%Mg (PT10M), and PLGA/TCP/15%Mg (PT15M). The bacterial adhesion and biofilm formation of Staphylococcus aureus were evaluated. The results indicated that the Mg-based scaffolds significantly inhibited bacterial adhesion and biofilm formation compared to PT, and the PT10M and PT15M exhibited significantly stronger anti-biofilm ability than PT5M. In vitro degratation tests revealed that the degradation of the Mg-based scaffolds caused an increase of pH, Mg(2+) concentration and osmolality, and the increased pH may be one of the major contributing factors to the antibacterial function of the Mg-based scaffolds. Additionally, the PT15M exhibited an inhibitory effect on cell adhesion and proliferation of MC3T3-E1 cells. In conclusion, the PLGA/TCP/Mg scaffolds co...Continue Reading

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Citations

Apr 21, 2018·Journal of Tissue Engineering and Regenerative Medicine·Yingqi ChenWilliam R Wagner
Mar 9, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Joanna BabilotteSylvain Catros
Feb 18, 2017·Biomedical Materials·M C Fernández-CalderónC Pérez-Giraldo
Aug 21, 2019·Journal of Biomedical Materials Research. Part a·Sarah Siefen, Michael Höck
Jan 29, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emily K BrooksMark T Ehrensberger
Feb 21, 2018·Journal of Biomedical Materials Research. Part a·Yuanyuan XuShengli Mi

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

SPSS

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