PMID: 5180997Feb 1, 1967Paper

Bacterial interference in experimental burns

The Journal of Experimental Medicine
B F Anthony, L W Wannamaker

Abstract

A standardized, full thickness, dermal burn in rabbits was used to study interference between strains of Staph. aureus inoculated on the wound surface. Several strains appeared equally capable of colonizing lesions and of preventing superinfection by other staphylococci inoculated at a later time. In addition, cross-infection between rabbits colonized by different strains (502A and Q461) and placed together in cages was prevented, presumably by the same mechanism. Interference appeared to be a strictly local phenomenon, since it did not occur when an animal was colonized by strain 502A at one burn site and subsequently challenged with strain Q461 at a separate lesion. For interference to occur, a minimal time interval (9 hr) was required between inoculation of the interfering strain and inoculation of the challenge strain. In vivo growth rates indicated rapid growth in the first 24 hr by the interfering strain but no detectable multiplication by the challenge strain. Heat-killed staphylococci, even in large numbers, were incapable of producing interference. Penicillin treatment of animals colonized by strain 502A (penicillin-sensitive) abolished interference with strain Q461 (penicillin-resistant). These findings indicate that ...Continue Reading

References

Jun 1, 1958·The Journal of Experimental Medicine·L W WANNAMAKER
Jun 1, 1963·Journal of General Microbiology·G I BARROW

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Citations

Dec 1, 1973·The Journal of Hygiene·A Hambraeus
Jan 1, 1969·The British Journal of Dermatology·H I MaibachH R Shinefield
Nov 1, 1975·The British Journal of Dermatology·S Selwyn
Jan 15, 1972·British Medical Journal·S Selwyn, H Ellis
Oct 1, 1977·The Journal of Hygiene·D E Pedgley, M R Tucker
Jan 1, 1970·Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology·K Wickman
Aug 1, 1970·Applied Microbiology·R AlyH R Shinefield
Dec 1, 1975·Bacteriological Reviews·K G Hardy
Feb 1, 1983·Infection and Immunity·R FreterK E Carey

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