Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats

Reproductive Toxicology
Mallikarjuna M ReddyPallu Reddanna

Abstract

Microbial infections, localized as well as systemic, are known to cause transitive or permanent male infertility. However, the mechanisms of infection-induced infertility are largely unknown. Earlier reports showed that steroidogenesis and spermatogenesis are affected during bacterial lipopolysaccharide (LPS)-induced acute inflammation. The present study used an LPS rat model to investigate the role of oxidative stress in spermatogenesis. Intraperitoneal administration of bacterial LPS (5mg/kg body weight) to adult male albino rats elevated testicular malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE), and decreased the activities of testicular antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. The GSH/GSSG ratio also decreased significantly. Time series analysis revealed transitory oxidative stress and expression of inflammatory mediators such as interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) from 3h to 12h after LPS. Testicular expression of steroidogenic acute regulatory (StAR) protein decreased to 24h, in correlation with damage to spermatogenesis. These data are consistent with oxidative stress as a major causal...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 24, 1976·Biochimica Et Biophysica Acta·J A Buege, S D Aust
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
Jan 1, 1985·Methods in Enzymology·C GuthenbergB Mannervik
Aug 8, 1994·FEBS Letters·F BauchéB Jégou
Sep 1, 1997·Journal of Neurochemistry·B Halliwell, J M Gutteridge
Jan 1, 1997·Reviews of Reproduction·M P Hedger
Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D M Stocco
Oct 28, 1999·Journal of Cellular Biochemistry·S BernardiniG Federici
May 19, 2000·The Proceedings of the Nutrition Society·S K Powers, S L Lennon
Nov 21, 2000·Free Radical Biology & Medicine·A V Rao, C Shaha
May 30, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·E Anton
Oct 14, 2003·Reproductive Toxicology·Frank InyangAnthony E Archibong
Dec 6, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Esragül AkinciMehmet Deveer
Oct 27, 2004·Reproductive Toxicology·Elangovan SelvakumarPalaninathan Varalakshmi
Dec 29, 2004·Human Fertility : Journal of the British Fertility Society·A A Pacey, A Eley

❮ Previous
Next ❯

Citations

Dec 8, 2009·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalPremendu P Mathur
Apr 2, 2010·Oxidative Medicine and Cellular Longevity·Adel R A Abd-AllahSaleh A Al-Bakheet
Jul 19, 2011·PloS One·Sylvain LosdatFabrice Helfenstein
Aug 11, 2007·World Journal of Urology·Nuray YazihanAyse Kose Sargin
May 3, 2014·Systems Biology in Reproductive Medicine·Giulia CollodelCesare Castellini
Aug 21, 2014·Systems Biology in Reproductive Medicine·Francesco GiannessiRiccardo Ruffoli
Sep 15, 2015·Journal of Cellular Biochemistry·Balamurugan RamatchandirinChidambaram Prahalathan
Apr 9, 2013·Pharmacological Reports : PR·Anna GorącaBeata Skibska
Jan 10, 2012·European Journal of Pharmacology·Hamdy A A AlyZainy M Banjar
Sep 3, 2011·Zoology : Analysis of Complex Systems, ZACS·Lilian Franco-Belussi, Classius de Oliveira
Jan 5, 2011·Chemico-biological Interactions·Abdelkader E AshourAdel R A Abd-Allah
Sep 13, 2011·Reproduction in Domestic Animals = Zuchthygiene·G CollodelE Moretti
Jul 13, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Mustafa ImamoğluHaluk Sarihan
Jul 29, 2011·Molecular Reproduction and Development·Angireddy RajeshSuresh Yenugu
Jan 5, 2011·American Journal of Reproductive Immunology : AJRI·Barnali Biswas, Suresh Yenugu
Apr 7, 2010·Molecular and Cellular Endocrinology·Andreas Meinhardt, Mark P Hedger
Apr 1, 2016·Asian Journal of Andrology·Piyush PathakAlexander W Pastuszak
Dec 3, 2014·Fertility and Sterility·Edmund Y KoAshok Agarwal
May 14, 2016·General and Comparative Endocrinology·Hari Prakash Verma, Shio Kumar Singh
Jun 14, 2016·European Journal of Pharmacology·Františka HorváthováJozef Mihalik
Jan 15, 2016·Asian Journal of Andrology·Faiza RaoFei Sun
Dec 21, 2018·Andrologia·María Susana Theas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.