Bacterial melanin promotes recovery after sciatic nerve injury in rats

Neural Regeneration Research
Olga V GevorkyanAnichka S Hovsepyan

Abstract

Bacterial melanin, obtained from the mutant strain of Bacillus Thuringiensis, has been shown to promote recovery after central nervous system injury. It is hypothesized, in this study, that bacterial melanin can promote structural and functional recovery after peripheral nerve injury. Rats subjected to sciatic nerve transection were intramuscularly administered bacterial melanin. The sciatic nerve transected rats that did not receive intramuscular administration of bacterial melanin served as controls. Behavior tests showed that compared to control rats, the time taken for instrumental conditioned reflex recovery was significantly shorter and the ability to keep the balance on the rotating bar was significantly better in bacterial melanin-treated rats. Histomorphological tests showed that bacterial melanin promoted axon regeneration after sciatic nerve injury. These findings suggest that bacterial melanin exhibits neuroprotective effects on injured sciatic nerve, contributes to limb motor function recovery, and therefore can be used for rehabilitation treatment of peripheral nerve injury.

References

Jan 1, 1988·Acta Neuropathologica·M Röyttä, V Salonen
Nov 20, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·G TerenghiS M Hall
Oct 4, 2002·Muscle & Nerve·Francisco Castañeda, Rolf K H Kinne
May 2, 2003·The Journal of Comparative Neurology·Ranjan Gupta, Oswald Steward
May 17, 2007·Neuroscience and Behavioral Physiology·O V GevorkyanA S Sagiyan
Aug 30, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·L P ManvelianT R Petrosian
Aug 31, 2010·Journal of Neurosurgery·Jonathan RothShimon Rochkind
Mar 1, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Tigran R PetrosyanLevon R Manvelyan

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Citations

Dec 16, 2020·ACS Biomaterials Science & Engineering·Adrián MagazJonny J Blaker

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