Bacterial meningitis: epidemiology, pathogenesis and management update.

Drugs
Yuliya Nudelman, Allan R Tunkel

Abstract

Bacterial meningitis continues to be an important disease throughout the world and can be a life-threatening emergency if not suspected, appropriately diagnosed and managed expeditiously. The epidemiology of bacterial meningitis has changed dramatically over the last 20 years, primarily as a result of the introduction of conjugate vaccines against the common meningeal pathogens, such that in the developed world where vaccination is routinely utilized, bacterial meningitis has become a disease of adults rather than of infants and children. The management approach to patients with suspected or proven bacterial meningitis includes emergent cerebrospinal fluid analysis and initiation of appropriate antimicrobial and adjunctive therapies. The choice of empirical antimicrobial therapy is based on the patient's age and underlying disease status; once the infecting pathogen is isolated, antimicrobial therapy can be modified for optimal treatment. Many patients with suspected or proven bacterial meningitis should also receive adjunctive dexamethasone therapy. This is based on experimental animal model data which demonstrated that the subarachnoid space inflammatory response that results from antimicrobial-induced bacterial lysis can con...Continue Reading

References

Dec 1, 1975·The American Journal of Medicine·R J MangiV T Andriole
Sep 17, 1992·The New England Journal of Medicine·V Quagliarello, W M Scheld
Apr 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M Musher
Apr 1, 1992·Clinical Microbiology Reviews·L D Gray, D P Fedorko
May 1, 1991·Reviews of Infectious Diseases·C F DeckerC U Tuazon
Jan 1, 1991·Reviews of Infectious Diseases·J BerenguerE Bouza
Feb 1, 1990·The Pediatric Infectious Disease Journal·W J RodriguezS Akram
Apr 15, 1990·Annals of Internal Medicine·A R TunkelW M Scheld
Jan 1, 1990·Intensive Care Medicine·B Genton, J P Berger
Dec 1, 1990·Archives of Internal Medicine·A K TakalaL van Alphen
Jan 1, 1990·Reviews of Infectious Diseases·J P BryanW M Scheld
Nov 1, 1987·Reviews of Infectious Diseases·A Verghese, G Gallemore
Jul 7, 1988·The New England Journal of Medicine·A G SjöholmH C Zanen
Mar 1, 1987·Medicine·L S SchlesingerD R Schaberg
Mar 1, 1985·Reviews of Infectious Diseases·L A BurmanB Trollfors
Sep 1, 1985·Reviews of Infectious Diseases·I W Fong, K B Tomkins
Mar 1, 1982·Medicine·P J SpagnuoloM S Rosenthal
Jul 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A M van FurthR van Furth
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·P KragsbjergP Olcén
Nov 1, 1994·The Journal of Infection·M T CollJ Lite
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A FijenJ Dankert
Jan 7, 1993·The New England Journal of Medicine·M L DurandM N Swartz
Jan 1, 1993·The Journal of Pediatrics·M UnhanandJ D Nelson
Jan 1, 1993·Medicine·D W Dunne, V Quagliarello
Apr 1, 1993·Clinical Microbiology Reviews·A R Tunkel, W M Scheld
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·A LercheV A Bohr
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·I Brook
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·O GarpenholtP Olcén
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B Lorber
Jan 1, 1997·Acta Paediatrica·C Luaces CubellsC L Latorre Otín
Feb 12, 1998·The New England Journal of Medicine·A SchuchatB A Perkins
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P DomingoJ Garau
Sep 24, 1998·The New England Journal of Medicine·M GalimandP Courvalin

❮ Previous
Next ❯

Citations

Mar 13, 2012·Critical Care Nursing Quarterly·Sarah Livesay, Susan D Ruppert
Apr 24, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P PellegrinoE Clementi
Jan 31, 2012·Neurologic Clinics·Amy A Pruitt
Oct 5, 2013·Journal of Chemotherapy·Giovanni CenderelloGiovanni Cassola
Dec 22, 2012·Expert Opinion on Pharmacotherapy·Susanna Esposito, Nicola Principi
Jul 13, 2016·Molecular and Cellular Probes·Hamidreza FarahaniBehzad Khansarinejad
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·Larry E Davis
Oct 12, 2012·Indian Journal of Pediatrics·N B MathurT K Mishra
Aug 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul MittalNemani V Prasadarao
Feb 21, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A S ShishovI A Blank

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.