Bacterial meningitis following introduction of Hib conjugate vaccine in northern Uganda

Annals of Tropical Paediatrics
Robert IrisoA Kisayke

Abstract

St Mary's Hospital, Lacor is in Gulu district in northern Uganda. Owing to conflict and insurgency, the majority of the hospital population live in internally displaced people's camps. There is ongoing public health surveillance of paediatric bacterial meningitis by the hospital. Before the introduction of Haemophilus influenza type b (Hib) conjugate vaccine in June 2002, Hib was the leading cause of bacterial meningitis in the area. All patients with suspected bacterial meningitis between April 2003 and August 2006 were recruited. Meningitis was confirmed by isolation of bacteria. During the study period, 4986 cases of suspected bacterial meningitis were identified, 395 of whom had purulent cerebrospinal fluid (CSF). A culture was obtained from 259 (65%): Streptococcus pneumoniae 132 (51%), H. influenzae 22 (8.5%), salmonella spp 85 (32.8%), Neisseria meningitidis 9 (3.5%) and others 11 (4.2%). Over the surveillance period, there was a remarkable decline in the prevalence of H. influenza meningitis to only three cases or fewer per year compared with 42 in 2001. The minimum incidence of Streptococcus pneumoniae meningitis among children under 5 years of age was 33.7/100,000 of population and it was more prevalent during the dry...Continue Reading

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Citations

Jul 9, 2010·Clinical Microbiology Reviews·Matthijs C BrouwerDiederik van de Beek
Mar 8, 2012·Future Microbiology·Nina M van Sorge, Kelly S Doran
Oct 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen H KeddyUNKNOWN Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)
Sep 26, 2015·Human Vaccines & Immunotherapeutics·Eugene LamMuireann Brennan
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Feb 9, 2010·Journal of Child Neurology·Richard IdroAngelina Kakooza-Mwesige
Feb 23, 2010·Current Opinion in Neurology·Andrew Riordan

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