PMID: 429305Apr 25, 1979Paper

Bacterial metabolism of corticoids with particular reference to the 21-dehydroxylation.

The Journal of Biological Chemistry
J WinterL Ponticorvo

Abstract

Clostridium paraputrificum, an obligate anaerobe recovered from human feces, reduces the alpha,beta-unsaturated carbonyl of deoxycorticosterone, corticosterone, cortisone, and cortisol. The same steroids are 21-dehydroxylated by Culture 116, recently isolated from human feces, and by a closely related organism, Eubacterium lentum. The 21-dehydroxylase has no effect on hydroxyl groups at carbon atoms 11 and 17.

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