PMID: 3320550Jan 1, 1987Paper

Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulation

Journal of Steroid Biochemistry
J Winter, V D Bokkenheuser

Abstract

Steroids undergoing enterohepatic circulation are exposed to bacterial metabolism particularly by obligate anaerobes which account for 99.99% of the fecal flora. The most common transformation is hydrolysis of conjugated steroids. The glucuronidases are synthesized by Escherichia coli and Bacteroides species. The bacterial catabolism of unconjugated steroids may be considered under several headings: 1. Reduction of ring-A due to clostridia species synthesizing specific enzymes; C. paraputrificum, 3 alpha,5 beta-reductase; C. innocuum, 3 beta,5 beta-reductase; and a new species C.J-1, 3 beta,5 alpha-reductase. 2. Reduction of the delta 5 bond by human fecal flora. The specific strain(s) synthesizing the enzyme have not yet been identified. 3. Reduction of 17-keto estrogens by the above mentioned ring-A reducing clostridia and by Eubacterium lentum. 4. Reduction of 17-keto androstenes by Bacteroides fragilis. 5. Desmolase mediated side chain cleavage at C17-C20 position of 17 alpha-hydroxysteroids by two new species Clostridium scindens and Eubacterium desmolans isolated from human and cat fecal flora respectively and by Clostridium cadavaris isolated from New York City sewage. 6. And 16 alpha- and 21-dehydroxylase by E. lentum a...Continue Reading

References

Sep 1, 1979·Contraception·H AdlercreutzT Fotsis
Aug 1, 1978·Journal of Steroid Biochemistry·P LombardiS L Gorbach
Nov 1, 1986·Applied and Environmental Microbiology·V D BokkenheuserS Locascio
Sep 12, 1984·Biochimica Et Biophysica Acta·J WinterB I Cohen
Nov 1, 1984·Journal of Steroid Biochemistry·J WinterV D Bokkenheuser
Sep 1, 1983·Journal of Clinical Microbiology·V D BokkenheuserE H Mosbach
Feb 1, 1982·Journal of Steroid Biochemistry·J WinterT L Glass
Oct 1, 1981·The New England Journal of Medicine·J LindenbaumJ R Saha

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Citations

Jun 24, 2008·Critical Reviews in Food Science and Nutrition·Theresa LarkinLee Astheimer
Mar 29, 2011·The Journal of Steroid Biochemistry and Molecular Biology·S KumpunR Lafont
Aug 7, 2008·International Journal of Pharmaceutics·Tiago SousaAbdul W Basit
Jul 7, 2015·BioMed Research International·Wirin LimopasmaneeSupanimit Teekachunhatean
Dec 3, 2008·Chemico-biological Interactions·Bronislava Cresnar, Marija Zakelj-Mavric
Feb 25, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Claudio GardanaPaolo Simonetti
Apr 9, 2017·The Journal of Biological Chemistry·Samuel J Pellock, Matthew R Redinbo
Jul 17, 2018·PloS One·Jessica G WallaceDeborah M Sloboda
Oct 18, 2020·Nature Reviews. Neuroscience·Brittany D NeedhamSarkis K Mazmanian
Jul 31, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Lina SchifferKarl-Heinz Storbeck
Apr 10, 2021·Journal of Agricultural and Food Chemistry·Tingyang AiJing Li
Oct 19, 2021·Frontiers in Cellular and Infection Microbiology·Pilar Cornejo UlloaMonique H van der Veen
Sep 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Carl JenkinsonDavid J Handelsman

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