PMID: 6990249Apr 1, 1980Paper

Bacterial mutagenicity and mammalian cell DNA damage by several substituted anilines

Mutation Research
D ZimmerB K Bhuyan

Abstract

Several substituted alkyl- and haloanilines were tested for their ability to mutate Salmonella typhimurium and to damage the DNA of mammalian (V79) cells. These results were correlated with their reported carcinogenicity. Of 9 suspected carcinogens, 4 were bacterial mutagens and 4 (out of 7 tested) damaged DNA of V79 cells. The following compounds were weakly mutagenic (less than 150 revertants/mumole): 4-fluoroaniline, 2,3-, 2,4-, 2,5- and 3,4-dimethylaniline, and 2-methyl-4-fluoroaniline. The following compounds were strong mutagens: 2,4,5-trimethylaniline, 2-methyl-4-chloro-, and 2-methyl-4-bromo-, 4-methyl-2-chloro-, 4-methyl-2-bromo- and 2-ethyl-4-chloroaniline. The compounds which damaged DNA in V79 cells were: 2 methyl-4-chloroaniline, 2-methyl-4-bromoaniline, 2,4,5- and 2,4,6-trimethylaniline.

References

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Citations

Jan 1, 1988·International Archives of Occupational and Environmental Health·M J Stasik
Feb 7, 2013·Journal of Biosciences·Milena RadakovicZoran Stanimirovic
Apr 1, 1989·Mutation Research·M E Kugler-SteigmeierC Schlatter
Nov 1, 1991·Mutation Research·N Danford
Mar 1, 1993·Mutation Research·M A JacksonM D Waters
Apr 1, 1984·Toxicology Letters·A HesbertC Cavelier
May 28, 2003·Toxicology·Miwa OkamuraKunitoshi Mitsumori
Nov 21, 2007·Chemical Research in Toxicology·Liang CuiPaul L Skipper
Apr 25, 1997·Journal of Toxicology and Environmental Health·S Shardonofsky, K Krishnan
Nov 6, 2009·Carcinogenesis·Paul L SkipperSteven R Tannenbaum
Dec 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S BoerenI M Rietjens
May 20, 2015·Regulatory Toxicology and Pharmacology : RTP·Nigel GreeneJoerg Wichard
Jan 4, 2017·Environmental Science & Technology·Melis MuzWerner Brack

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