Bacterial osteomyelitis in adults: evolving considerations in diagnosis and treatment

The American Journal of Medicine
D W Haas, M P McAndrew

Abstract

Bacterial osteomyelitis causes substantial morbidity worldwide, despite continued progress toward understanding its pathophysiology and optimal management. The approach to osteomyelitis depends upon the route by which bacteria gained access to bone, bacterial virulence, local and systemic host immune factors, and patient age. While imaging studies and nonspecific blood tests may suggest the diagnosis, an invasive technique is generally required to identify the causative pathogens. Given the paucity of comparative clinical trials, antibacterial regimen selection has been largely guided by knowledge of the relative activities and pharmacokinetics of individual drugs, supported by data from animal models. Definitive therapy often requires a combined medical and surgical approach. Newer microvascular and distraction osteogenesis techniques and the use of laser doppler allow more complete surgical resection of infected material while maintaining function. Despite recent advances, many patients with osteomyelitis fail aggressive medical and surgical therapy. More accurate diagnostic methods, better ways to assess and monitor the effectiveness of therapy, and novel approaches to eradicate sequestered bacteria are needed.

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References

Sep 1, 1979·Microbiological Reviews·M Rogolsky
Apr 1, 1976·AJR. American Journal of Roentgenology·M Majd, R S Frankel
Jun 30, 1978·JAMA : the Journal of the American Medical Association·P A MackowiakJ W Smith
Jan 1, 1978·Medicine·M J Raff, J C Melo
Jul 1, 1978·Journal of Biomedical Materials Research·R C NelsonT A Burton
Jun 1, 1978·Acta Orthopaedica Scandinavica·A S Carlsson
Oct 1, 1976·Annals of Internal Medicine·T J LouieS L Gorbach
Nov 1, 1976·Journal of Biomedical Materials Research·E P LautenschlagerP R Meyer
Oct 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H N UkwuR H Latham
Jan 1, 1992·AJR. American Journal of Roentgenology·D S Schauwecker
Sep 4, 1991·JAMA : the Journal of the American Medical Association·L G NewmanA Stagnaro-Green
Nov 15, 1991·Annals of Internal Medicine·H M Blumberg
Jun 1, 1991·Annals of Internal Medicine·L O Gentry
Mar 1, 1991·Antimicrobial Agents and Chemotherapy·L O Gentry, G Rodriguez-Gomez
Jan 1, 1990·Antimicrobial Agents and Chemotherapy·L O Gentry, G G Rodriguez
Jan 1, 1990·The Journal of Infectious Diseases·C W Norden, A Budinsky
Jul 1, 1990·British Journal of Plastic Surgery·T E GoodacreM D Brough
Apr 1, 1989·American Journal of Surgery·J H Calhoun, J T Mader
May 1, 1989·AJR. American Journal of Roentgenology·J E SeaboldP T Kirchner
Aug 1, 1989·The Journal of Bone and Joint Surgery. British Volume·L Sanzén, A S Carlsson
Jun 28, 1985·The American Journal of Medicine·J Wheat
Apr 1, 1988·Acta Orthopaedica Scandinavica·L Sanzén
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J W YoudasE Y Chao
May 1, 1987·The Journal of Bone and Joint Surgery. British Volume·M LynchB M Wroblewski
Jul 1, 1987·Clinical Orthopaedics and Related Research·D R GoreM P Murray
May 1, 1986·The Journal of Infectious Diseases·C W NordenK Niederriter
Oct 1, 1985·Radiology·M T ModicS Rehm
Jun 1, 1985·Acta Orthopaedica Scandinavica·S A MajidM S Siddiki

❮ Previous
Next ❯

Citations

Sep 28, 2013·The Journal of Antimicrobial Chemotherapy·Baek-Nam KimMyoung-Don Oh
Mar 22, 2008·AJNR. American Journal of Neuroradiology·C Y HsuT T F Shih
Jul 25, 2000·Postgraduate Medical Journal·J Ciampolini, K G Harding
Apr 8, 2003·International Orthopaedics·M M Muhdi, T A Hamdam
Apr 16, 2008·Antimicrobial Agents and Chemotherapy·Kyriaki KanellakopoulouHelen Giamarellou
Apr 2, 2008·Archives of Orthopaedic and Trauma Surgery·A L AkinyoolaA O Aboderin
Dec 25, 2010·Archives of Orthopaedic and Trauma Surgery·Y TanZhijun Pan
May 24, 2000·Comprehensive Therapy·D M Bamberger
Jun 22, 2001·The American Journal of the Medical Sciences·G KhatriP G Sohnle
Apr 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Noam EmanuelYechezkel Barenholz
Jan 4, 2012·Mayo Clinic Proceedings·Camelia E MarculescuDouglas R Osmon
Aug 31, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Cécile Gaujoux-VialaJean Marc Ziza
Nov 13, 2007·Solid State Nuclear Magnetic Resonance·Joshua M BraySteven D Beyea
Jul 14, 2007·Médecine et maladies infectieuses·M ElouennassM Ouaaline
Nov 28, 2006·Best Practice & Research. Clinical Rheumatology·Irene G Sia, Elie F Berbari
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·P A Comeau, M J Filiaggi
Nov 14, 2015·Journal of Orthopaedics·Leonard Charles MaraisTheo Le Roux
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Michael S TimmersGerrolt N Jukema
Apr 8, 2014·The Journal of Arthroplasty·Jai-Gon SeoSang-Min Kim
Dec 4, 2009·Expert Opinion on Pharmacotherapy·I ByrenB A Lipsky
Jun 5, 2002·The Journal of Trauma·Thomas GrossAndreas F Widmer
May 7, 2004·The Journal of Trauma·Sven A F TulnerR K Marti
Nov 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael A NowakMark A Beilke
Jun 6, 2007·Clinical Orthopaedics and Related Research·McKinley C LawsonKristi S Anseth
Jan 14, 2011·Plastic and Reconstructive Surgery·George Cierny
Feb 25, 2009·Expert Opinion on Pharmacotherapy·Juan García-Lechuz, Emilio Bouza
Jul 4, 2009·Strategies in Trauma and Limb Reconstruction·Andreas Heinrich Tiemann, Gunther O Hofmann
Nov 9, 2019·International Orthopaedics·Willem OosthuysenNando Ferreira
Dec 20, 2007·Spine·Shafic Said Al-NammariKhai S Lam
Jun 3, 1999·Medicine·J M García-LechuzE Bouza
Apr 2, 1999·Clinical Orthopaedics and Related Research·J T MaderJ Calhoun
Oct 24, 2006·Foot & Ankle International·John M EmbilLindsay E Nicolle
Sep 10, 2013·The Cochrane Database of Systematic Reviews·Lucieni O Conterno, Marilia D Turchi
Jul 27, 2017·BMC Infectious Diseases·Chih-Hsiang FangYen-Chun Chen
Mar 4, 1998·Hospital Practice·T P ArcherE L Mazzaferri
May 17, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Samit Kumar NandiAmit Bandyopadhyay
Oct 3, 2002·Clinical Orthopaedics and Related Research·Douglas R Osmon, Elie F Berbari

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