Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms

Drug Discoveries & Therapeutics
Masaki IshiiKazuhisa Sekimizu

Abstract

Diabetes and obesity result from sucrose-induced hyperglycemia. Prevention of hyperglycemia contributes to inhibit the onset of these life-related diseases. Here we show that polysaccharides obtained from soil bacteria inhibit sucrose-induced hyperglycemia in an in vivo silkworm evaluation system. Ethanol precipitates of extracellular polysaccharides were prepared from viscous bacterial colonies. Among 24 samples obtained from different bacterial species, oral administration of 6 samples from Rhizobium altiplani, Cupriavidus sp., Paenibacillus polymyxa, Pantoea eucalypti, Variovorax boronicumulans, and Xanthomonas cynarae suppressed sucrose-induced hyperglycemia in silkworm insect larvae. The R. altiplani fraction treated further with DNase I, RNase A, and proteinase K, followed by phenol extraction also exhibited suppressive activity. Our results suggest that silkworms provide an efficient screening system of bacterial polysaccharides that inhibit sucrose-induced hyperglycemia.

References

Jun 25, 2002·Microbial Pathogenesis·Chikara KaitoKazuhisa Sekimizu
Jun 29, 2010·Nature Reviews. Microbiology·Bernd H A Rehm
Apr 12, 2011·PloS One·Yasuhiko MatsumotoKazuhisa Sekimizu
May 13, 2011·Trends in Biotechnology·Filomena FreitasMaria A M Reis
Dec 4, 2012·International Journal of Molecular Sciences·Uchechukwu U NwodoAnthony I Okoh
May 23, 2015·Drug Discoveries & Therapeutics·Don Daniel NwiboKazuhisa Sekimizu
May 30, 2015·Scientific Reports·Yasuhiko MatsumotoKazuhisa Sekimizu
Mar 11, 2016·Drug Discoveries & Therapeutics·Yasuhiko Matsumoto, Kazuhisa Sekimizu
Mar 23, 2017·Frontiers in Microbiology·Suresh PantheeKazuhisa Sekimizu

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