Bacterial pore-forming proteins as anthelmintics.

Invertebrate Neuroscience : in
Yan Hu, Raffi V Aroian

Abstract

Crystal (Cry) proteins are made by the Gram-positive bacterium Bacillus thuringiensis (Bt). Cry proteins are pore-forming proteins and are the most widely used biological insecticides in the world. Our laboratory found some Cry proteins are highly effective against a broad range of nematodes (roundworms). Here, we discuss our results of Cry protein activity against intestinal roundworms. Both Cry5B and Cry21A have therapeutic activities against infections of the roundworm Heligmosomoides polygyrus bakeri in mice. Cry5B also shows highly therapeutic activity against Ancylostoma ceylanicum infection in hamsters. A. ceylanicum is a minor hookworm parasite of humans, and it is closely related to the more prevalent Ancylostoma duodenale. In addition, Cry proteins show excellent combinatorial therapeutic properties with nicotinic acetylcholine receptor (nAChR) agonists, one of the two classes of compounds approved by the World Health Organization for the treatment for intestinal roundworms in humans. Given their non-toxicity to humans and their broad spectrum of nematicidal action, Cry proteins show great potential as next-generation anthelmintics.

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Citations

Nov 13, 2012·PLoS Neglected Tropical Diseases·Yan HuRaffi V Aroian
Jun 14, 2016·BioMed Research International·Luis Javier Mendoza-EstradaGuadalupe Peña-Chora
Jan 9, 2015·PLoS Neglected Tropical Diseases·Douglas P JasmerMakedonka Mitreva
May 27, 2020·PLoS Neglected Tropical Diseases·Douglas P JasmerMakedonka Mitreva
Aug 14, 2019·Frontiers in Genetics·Douglas P JasmerMakedonka Mitreva

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.