Apr 13, 2020

Generalized gametic relationships for flexible analyses of parent-of-origin effects

BioRxiv : the Preprint Server for Biology
Norbert ReinschI. Blunk

Abstract

Genomic imprinting causes alleles to influence the phenotype in a parent-of-origin-specific manner. In attempts to determine the effects of imprinted loci, gametic relationship matrices have widely been used in pedigree-based parent-of-origin analyses of population data. One drawback of this is the size of these matrices because they represent each individual by two gametic effects. Significantly fewer equations are needed if a previously published reduced imprinting model is used that relates observations from progeny without its own offspring to the transmitting abilities of their parents. This can be accomplished using a numerator relationship matrix, with only a single row and column per parent and ancestors. However, the reduced model is not applicable when the parents have records. To better handle the curse of dimensionality, we propose a combination of average gametic effects (transmitting abilities) for individuals without their own records and single gametic effects for others. The generalized gametic relationship matrix is the covariance of this mixture of genetic effects that allows for a significant reduction in the number of equations in gametic models depending on the trait, depth of pedigree, and population stru...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Pathogenic Aspects
Immune System
Hemorrhagic Fever, Ebola
Pathogenesis
Virus
Ebola virus
Genome
Sequence Determinations, RNA
RNA Viruses
Ebolavirus

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

International Review of Cytology
L MACHLIS, E RAWITSCHER-KUNKEL
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
B Tier, J Sölkner
Journal of Animal Science
A Ruvinsky
© 2020 Meta ULC. All rights reserved