Bacterial sinusitis and otitis media following influenza virus infection in ferrets.

Infection and Immunity
Ville T PeltolaJonathan A McCullers

Abstract

Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections. In this study we sought to determine whether the frequency and character of secondary pneumococcal infections differed depending on the strain of influenza virus that preceded bacterial challenge. In young ferrets infected with influenza virus and then challenged with pneumococcus, influenza viruses of any subtype increased bacterial colonization of the nasopharynx. Nine out of 10 ferrets infected with H3N2 subtype influenza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected with either an H1N1 influenza A virus or an influenza B virus did so. These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism.

References

Feb 1, 1979·The Journal of Infectious Diseases·B H HamoryJ M Gwaltney
Oct 9, 1975·The New England Journal of Medicine·F O EvansJ M Gwaltney
Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Feb 1, 1991·The Journal of Pediatrics·H MoriuchiY Numazaki
Dec 1, 1980·American Journal of Epidemiology·P F WrightD T Karzon
Feb 7, 1998·American Journal of Public Health·L SimonsenL B Schonberger
May 20, 1999·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G S Giebink
Mar 18, 2000·The Journal of Infectious Diseases·L SimonsenN J Cox
May 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K L O'BrienS F Dowell
Feb 13, 2001·Vaccine·J O Klein
Feb 15, 2001·The New England Journal of Medicine·J EskolaUNKNOWN Finnish Otitis Media Study Group
Feb 28, 2001·Microbes and Infection·A H ReidT G Fanning
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ville PeltolaOlli Ruuskanen
Mar 28, 2003·The Journal of Infectious Diseases·Jonathan A McCullers, Kimberly C Bartmess
Apr 15, 2003·Clinical Microbiology Reviews·Terho Heikkinen, Tasnee Chonmaitree
Jan 20, 2004·The Pediatric Infectious Disease Journal·Ville T Peltola, Jonathan A McCullers
Jul 10, 2004·The Journal of Infectious Diseases·Jonathan A McCullers
Jul 13, 2004·Nature Medicine·Shabir A MadhiUNKNOWN Vaccine Trialist Group
Sep 21, 2004·The Journal of Infectious Diseases·Terho HeikkinenTaina Juven
Mar 23, 2005·Vaccine·Timothy F MurphyDavid L Klein
Jun 18, 2005·The Journal of Infectious Diseases·Ville T PeltolaJonathan A McCullers
Jul 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Donald R OlsonStephen S Morse

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Citations

Dec 31, 2008·The Journal of Infectious Diseases·Asa KarlströmJonathan A McCullers
Feb 23, 2010·The Journal of Infectious Diseases·Maria HedlundFang Fang
Sep 9, 2010·The Journal of Infectious Diseases·Jonathan A McCullersBirgitta Henriques Normark
Sep 21, 2011·The Journal of Infectious Diseases·Kirsty R ShortOdilia L Wijburg
Nov 22, 2008·The Journal of Antimicrobial Chemotherapy·Jean-Marie DuezAndré Péchinot
Feb 6, 2010·The Pediatric Infectious Disease Journal·Hannah C MooreUNKNOWN Kalgoorlie Otitis Media Research Project Team
Jul 19, 2006·Clinical Microbiology Reviews·Jonathan A McCullers
Jan 16, 2013·Infection and Immunity·Kirsty R ShortOdilia L Wijburg
Jan 16, 2013·Infection and Immunity·Michael J Mina, Keith P Klugman
Aug 4, 2011·Disease Models & Mechanisms·Jessica A BelserTerrence M Tumpey
Mar 27, 2007·PLoS Pathogens·Jonathan A McCullersVincent A Fischetti
Apr 5, 2013·PLoS Pathogens·Amber M SmithAlan S Perelson
Oct 25, 2012·Emerging Infectious Diseases·Matti KiupelSteven R Bolin
May 10, 2012·Future Microbiology·Kirsty R ShortDimitri A Diavatopoulos
Sep 8, 2009·The Veterinary Clinics of North America. Exotic Animal Practice·Lauren V Powers
Sep 7, 2013·Scandinavian Journal of Immunology·Y Furuya, A Müllbacher
Mar 31, 2015·Virology·T Enkirch, V von Messling
Jan 22, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·AliReza EshaghiSteven J Drews
Jan 30, 2009·Antiviral Research·Dale L Barnard
Oct 15, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Catalina GutierrezJuan Pablo Torres
Nov 18, 2017·Viral Immunology·Amber M Smith, Victor C Huber
Jul 15, 2016·Microbiology and Molecular Biology Reviews : MMBR·Jessica A BelserTaronna R Maines
Dec 22, 2009·Expert Review of Vaccines·Rogier BodewesAlbert D M E Osterhaus
Dec 12, 2017·The Journal of Infectious Diseases·Vikki G NolanJonathan A McCullers
Feb 13, 2019·The Pediatric Infectious Disease Journal·Catherine E Foster, Sheldon L Kaplan
Aug 24, 2012·Expert Review of Vaccines·Birgit SimellUNKNOWN Pneumococcal Carriage Group
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudra BhowmickJohn M Leong
Dec 7, 2018·Frontiers in Immunology·Shigeo HanadaJane C Deng
May 2, 2017·Laryngoscope Investigative Otolaryngology·Nyall R London, Andrew P Lane
Jan 4, 2020·The European Respiratory Journal·Carlos J OrihuelaJeremy S Brown
Aug 10, 2020·IUBMB Life·Rasoul MirzaeiSajad Karampoor
Feb 6, 2020·Journal of Translational Internal Medicine·Arefeh BabazadehSoheil Ebrahimpour
Jun 24, 2021·PloS One·Shinya YamamotoHiroshi Yotsuyanagi

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