Bacterial social interactions drive the emergence of differential spatial colony structures

BMC Systems Biology
Andrew E Blanchard, Ting Lu

Abstract

Social interactions have been increasingly recognized as one of the major factors that contribute to the dynamics and function of bacterial communities. To understand their functional roles and enable the design of robust synthetic consortia, one fundamental step is to determine the relationship between the social interactions of individuals and the spatiotemporal structures of communities. We present a systematic computational survey on this relationship for two-species communities by developing and utilizing a hybrid computational framework that combines discrete element techniques with reaction-diffusion equations. We found that deleterious interactions cause an increased variance in relative abundance, a drastic decrease in surviving lineages, and a rough expanding front. In contrast, beneficial interactions contribute to a reduced variance in relative abundance, an enhancement in lineage number, and a smooth expanding front. We also found that mutualism promotes spatial homogeneity and population robustness while competition increases spatial segregation and population fluctuations. To examine the generality of these findings, a large set of initial conditions with varying density and species abundance was tested and analy...Continue Reading

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Related Concepts

C1S
Fluctuation
Cell Movement
Superinfection
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Cell Motility
Toxin
Diffusion Weighted Imaging
Colony Morphology
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