Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

Research : a Science Partner Journal
Yan-Wen BaoFu-Gen Wu

Abstract

Biological synthetic methods of nanoparticles have shown great advantages, such as environmental friendliness, low cost, mild reaction conditions, and enhanced biocompatibility and stability of products. Bacteria, as one of the most important living organisms, have been utilized as bioreducing nanofactories to biosynthesize many metal nanoparticles or compounds. Here, inspired by the disinfection process of KMnO4, we for the first time introduce bacteria as both the template and the reducing agent to construct a novel tumor microenvironment-responsive MnO x -based nanoplatform for biomedical applications in various aspects. It is found that the bacterium/MnO x -based nanospindles (EM NSs) can efficiently encapsulate the chemotherapeutic agent doxorubicin (DOX), leading to the fluorescence quenching of the drug. The as-formed DOX-loaded EM NSs (EMD NSs) are proven to be decomposed by glutathione (GSH) and can simultaneously release DOX and Mn2+ ions. The former can be utilized for sensitive fluorescence-based GSH sensing with a limit of detection as low as 0.28 μM and selective cancer therapy, while the latter plays important roles in GSH-activated magnetic resonance imaging and chemodynamic therapy. We also demonstrate that...Continue Reading

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Citations

Sep 21, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shu ShengXuesi Chen
May 12, 2021·ACS Nano·Xiaotong ChengFu-Gen Wu
May 28, 2021·Research : a Science Partner Journal·Xiulin YiFu-Gen Wu
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
Nov 4, 2021·Advanced Healthcare Materials·Zihao Wang, Fu-Gen Wu

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Methods Mentioned

BETA
transmission
dynamic light scattering
X-ray
biosensing
Assay
xenograft

Software Mentioned

Nano Measurer

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