Bacterial translation elongation factor EF-Tu interacts and colocalizes with actin-like MreB protein.

Proceedings of the National Academy of Sciences of the United States of America
Hervé Joël Defeu SoufoPeter L Graumann

Abstract

We show that translation initiation factor EF-Tu plays a second important role in cell shape maintenance in the bacterium Bacillus subtilis. EF-Tu localizes in a helical pattern underneath the cell membrane and colocalizes with MreB, an actin-like cytoskeletal element setting up rod cell shape. The localization of MreB and of EF-Tu is interdependent, but in contrast to the dynamic MreB filaments, EF-Tu structures are more static and may serve as tracks for MreB filaments. In agreement with this idea, EF-Tu and MreB interact in vivo and in vitro. Lowering of the EF-Tu levels had a minor effect on translation but a strong effect on cell shape and on the localization of MreB, and blocking of the function of EF-Tu in translation did not interfere with the localization of MreB, showing that, directly or indirectly, EF-Tu affects the cytoskeletal MreB structure and thus serves two important functions in a bacterium.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T BlumenthalD Smith
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B D BeckA Jacobson
Jul 1, 1979·European Journal of Biochemistry·B D Beck
May 6, 1976·Nature·G R Jacobson, J P Rosenbusch
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A V Furano
Sep 6, 1990·Nature·K C HolmesW Kabsch
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H WolfA Parmeggiani
Jun 1, 1981·Cell·F S Young, A V Furano
Oct 14, 1998·Journal of Molecular Biology·L KrásnýJ Jonák
Feb 17, 2000·The EMBO Journal·P J LewisJ Errington
Sep 7, 2001·Nature·F van den EntJ Löwe
Jan 18, 2003·Developmental Cell·Rut Carballido-López, Jeff Errington
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zemer GitaiLucy Shapiro
Oct 23, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peter L Graumann, Hervé Joël Defeu Soufo
Nov 19, 2004·The Journal of Biological Chemistry·Osigwe EsueYiider Tseng
Mar 9, 2005·Molecular Microbiology·Alex Formstone, Jeffery Errington
Aug 24, 2005·Nature Structural & Molecular Biology·Stephane R Gross, Terri Goss Kinzy
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Arun V DivakaruniJames W Gober
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·So Yeon KimW E Moerner
Feb 6, 2007·Current Biology : CB·Ramanujam SrinivasanMohan K Balasubramanian
May 18, 2007·Annual Review of Microbiology·Peter L Graumann
Nov 15, 2008·The EMBO Journal·Daisuke ShiomiHironori Niki
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·S Anisah AlyahyaChristine Jacobs-Wagner
Feb 5, 2009·Molecular Microbiology·Yoshikazu KawaiJeffery Errington
Feb 18, 2009·Molecular Microbiology·Purva VatsLawrence Rothfield

❮ Previous
Next ❯

Citations

Sep 6, 2012·Applied Microbiology and Biotechnology·Vic NorrisJason A Rosenzweig
Dec 12, 2012·Molecular & Cellular Proteomics : MCP·Malvina PapanastasiouAnastassios Economou
Jul 16, 2010·Cold Spring Harbor Perspectives in Biology·Joshua W Shaevitz, Zemer Gitai
Jul 19, 2011·Applied and Environmental Microbiology·Edward M FoxKieran Jordan
Dec 15, 2010·Journal of Bacteriology·Carmen ButanJacqueline L S Milne
Jan 10, 2012·International Journal of Cell Biology·Masahiro KumetaKunio Takeyasu
Jun 29, 2011·Journal of Molecular Microbiology and Biotechnology·Frédérique PompeoAnne Galinier
Nov 20, 2013·PloS One·Lily MijouinMarc G J Feuilloley
Jun 25, 2013·Theory in Biosciences = Theorie in Den Biowissenschaften·Vic NorrisJean-Nicolas Audinot
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina Y GottshallNaomi L Ward
Oct 22, 2013·Nature Chemical Biology·Daniel Castro-RoaNikolay Zenkin
Feb 21, 2016·Trends in Plant Science·Jan de VriesSven B Gould
Feb 14, 2015·Journal of Molecular Biology·Hervé Joël Defeu SoufoPeter L Graumann
Oct 16, 2015·Proteomics·Malvina PapanastasiouAnastassios Economou
May 3, 2012·Molecular Microbiology·Hannah H TusonDouglas B Weibel
Jul 19, 2012·Molecular Microbiology·Anastasiya A Yakhnina, Zemer Gitai
Jul 16, 2013·The Biochemical Journal·Betül Kaçar, Eric A Gaucher
Oct 22, 2015·Annual Review of Microbiology·Ned S Wingreen, Kerwyn Casey Huang
Sep 15, 2016·Nucleic Acids Research·Anne PlochowietzAchillefs N Kapanidis
Sep 3, 2014·PloS One·Jun LiGeorge M Church
Jan 1, 2012·Life·Vic Norris, Patrick Amar
Jan 1, 2011·Life·Victor Norris, Yohann Grondin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved