Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon

American Journal of Surgery
Stefan FritzJens Werner

Abstract

The clinical course of acute necrotizing pancreatitis (ANP) is determined by the superinfection of pancreatic necrosis. To date, the pathophysiology of the underlying bacterial translocation is poorly understood. The present study investigated the bacterial source of translocation. A terminal loop ileostomy was applied in rats. Selective digestive decontamination (SDD) of either the small bowel or the colon was performed. After 3 days of SDD, severe ANP was induced. At 24 hours, bacterial translocation was assessed by cultures of bowel mucosa, mesenteric lymph nodes, and pancreas using a scoring system (0-4). Without SDD, pancreatic infection was present in all cases with an average score of 2.67. Colon SDD reduced pancreatic superinfection to 1.67 (not significant). SDD of the small bowel significantly reduced superinfection to 1.0 (P < .005). Bacterial translocation from the colon is less frequent than translocation from the small bowel. Thus, the small bowel seems to be the major source of enteral bacteria in infected pancreatic necrosis.

Associated Clinical Trials

References

Jan 1, 1992·Annals of Surgery·J SchmidtA L Warshaw
Aug 1, 1995·Digestive Diseases and Sciences·F G MoodyD M Muncy
Feb 1, 1995·American Journal of Surgery·N S RunkelF G Moody
Jan 1, 1993·American Journal of Surgery·D S MedichK K Lee
Oct 13, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·R Isenmann, H G Beger
Dec 29, 2000·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·M MutingaP A Banks
May 26, 2001·Langenbeck's Archives of Surgery·J Slavin, J P Neoptolemos
Jul 10, 2001·The British Journal of Surgery·B GloorM W Büchler
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T BlumP G Lankisch
Oct 16, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Stephan SamelStefan Post
Jun 6, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I D Van FeliusH G Gooszen
Jan 10, 2004·Journal of Hepato-biliary-pancreatic Surgery·Christos DervenisEfthimios Hatzitheoklitos
May 1, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·L P van MinnenL M A Akkermans
May 17, 2007·Scandinavian Journal of Gastroenterology·Jens WernerMarkus W Büchler

❮ Previous
Next ❯

Citations

Sep 20, 2011·Applied and Environmental Microbiology·Jacoline GerritsenGer T Rijkers
May 2, 2012·BMC Gastroenterology·Lauri PynnönenJyrki Tenhunen
Jan 1, 2014·World Journal of Gastroenterology : WJG·Jun-Jun SunYu-Ming Zhang
May 24, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Gabriel J SeifertUwe A Wittel
May 24, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masataka KikuyamaTakafumi Kurokami
Aug 17, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Olaf J BakkerHein G Gooszen
Mar 26, 2014·Nature Reviews. Gastroenterology & Hepatology·Olaf J BakkerHein G Gooszen
Nov 20, 2014·The New England Journal of Medicine·Olaf J BakkerUNKNOWN Dutch Pancreatitis Study Group
Jun 13, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alison S F ElderDani-Louise Dixon
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alison S F ElderDani-Louise Dixon
Jun 8, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Ying Liu, He-Sheng Luo
Oct 1, 2011·Advances in Surgery·Jordan R Stem, Jeffrey B Matthews
Sep 21, 2010·Life Sciences·Thilo HackertJens Werner
Jan 30, 2016·Expert Review of Gastroenterology & Hepatology·Piet J LodewijkxUNKNOWN Dutch Pancreatitis Study Group
Nov 26, 2013·The British Journal of Surgery·D W da CostaO J Bakker
Jan 15, 2015·The Journal of Small Animal Practice·C Mansfield, T Beths
Oct 4, 2014·The Journal of Surgical Research·Konrad SchulzErnst von Dobschuetz
May 22, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pankaj Singh, Pramod Kumar Garg
Jun 24, 2016·Digestive Diseases·Marco J Bruno, UNKNOWN Dutch Pancreatitis Study Group
Jun 22, 2018·Apoptosis : an International Journal on Programmed Cell Death·Meng-Er CenGang Wang
Aug 1, 2018·Expert Opinion on Biological Therapy·Na YangWeiqin Li
Aug 26, 2017·Gut·Sven M van DijkUNKNOWN Dutch Pancreatitis Study Group
Mar 10, 2016·Nature Reviews. Gastroenterology & Hepatology·Janneke van GrinsvenUNKNOWN Dutch Pancreatitis Study Group
Sep 14, 2012·Journal of Clinical Gastroenterology·Gabriele CapursoGianfranco Delle Fave
Jan 18, 2013·Indian Journal of Anaesthesia·Soumya S NathDebashis Roy
May 30, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luqiao HuangChunbao Guo
Nov 7, 2019·Physiological Reports·Fahad MunirZhang Qiyu
Dec 19, 2019·Critical Reviews in Microbiology·Jinbo LiuXianming Xia
Feb 25, 2020·European Journal of Gastroenterology & Hepatology·Elmas Biberci KeskinHakan Şentürk
Jul 9, 2020·Cancer Medicine·Jiwei SunLili Chen
Mar 15, 2016·World Journal of Gastroenterology : WJG·Ai-Lin WeiZhao-Da Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
I D Van FeliusHein G Gooszen
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Alison S F ElderDani-Louise Dixon
Critical Care : the Official Journal of the Critical Care Forum
Stefan FritzJens Werner
© 2021 Meta ULC. All rights reserved