Rats receiving nonlethal thermal burns over 20 or 40% of their total body surface area were tested at various intervals for the translocation of indigenous bacteria from their gastrointestinal tracts to their mesenteric lymph nodes, peritoneal cavities, and bloodstreams. No indigenous bacteria were cultured from these organs of control rats or from rats receiving 20% burns. However, 44% of the rats receiving 40% burns exhibited viable Escherichia coli, Proteus mirabilis, Staphylococcus sp. and Clostridium sp. in their mesenteric lymph nodes 2 days after thermal injury. Bacterial translocation after burn stress also was tested in antibiotic-decontaminated rats monoassociated with E. coli. E. coli attained population levels in these animals of 10(8) to 10(9) per g cecum. E. coli translocated to 100% of the mesenteric lymph nodes of both the control and 40% burned rats. However, E. coli translocated at a greater incidence to the spleens, livers, and peritoneal cavities of the burned rats compared with translocation to these organs in control rats. The numbers of E. coli translocating to the mesenteric lymph nodes, spleens, and livers also were greater in the 40% burned rats than in control rats. By 14 days after thermal injury, th...Continue Reading
Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model.
Inhibition of translocation of viable Escherichia coli from the gastrointestinal tract of mice by bacterial antagonism.
Antagonism among the normal anaerobic bacteria of the mouse gastrointestinal tract determined by immunofluorescence.
A sequential, prospective analysis of immunologic abnormalities and infection following severe thermal injury
Translocation of microorganisms across the intestinal wall of the rat: effect of microbial size and concentration
Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types.
Inhibition of Escherichia coli translocation from the gastrointestinal tract by normal cecal flora in gnotobiotic or antibiotic-decontaminated mice.
Promotion of the translocation of enteric bacteria from the gastrointestinal tracts of mice by oral treatment with penicillin, clindamycin, or metronidazole.
In vivo and in vitro antagonism of intestinal bacteria against Shigellaflexneri. II. The inhibitory mechanism
ECOLOGICAL MECHANISM CONTROLLING GROWTH OF ESCHERICHIA COLI IN CONTINUOUS FLOW CULTURES AND IN THE MOUSE INTESTINE
Guidelines for the scientific review of enteral food products for special medical purposes. Prepared for the Center for Food Safety and Applied Nutrition, Food and Drug Administration
Exposure of the peritoneal cavity to air regulates early inflammatory responses to surgery in a murine model
Influence of decontamination on induction of arthritis in Lewis rats by cell wall fragments of Eubacterium aerofaciens. Arthropathic properties of indigenous anaerobic bacteria
Escherichia coli transcytosis in a Caco-2 cell model: implications in neonatal necrotizing enterocolitis
Mechanisms of postburn intestinal barrier dysfunction in the rat: roles of epithelial cell renewal, E-cadherin, and neutrophil extravasation
Mesenteric lymph duct ligation attenuates lung injury and neutrophil activation after intraperitoneal injection of endotoxin in rats
Effect of gaseous hydrogen sulphide on growth performance and cecal microbial diversity of weaning pigs.
Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock
Confirmation and prevention of intestinal barrier dysfunction and bacterial translocation caused by methotrexate
Mesenteric lymph duct drainage attenuates acute lung injury in rats with severe intraperitoneal infection
Effects of octreotide acetate and Saccharomyces boulardii on bacterial translocation in an experimental intestinal loop obstruction model of rats
Translocation of bacteria due to direct mucosal damage caused by Gastrografin. An experimental study in newborn rats
Lack of correlation between failure of gut barrier function and septic complications after major upper gastrointestinal surgery
Green fluorescent protein labeling Escherichia coli TG1 confirms intestinal bacterial translocation in a rat model of chemotherapy
The analysis of the defense mechanism against indigenous bacterial translocation in X-irradiated mice
Chronic ethanol intake and burn injury: evidence for synergistic alteration in gut and immune integrity
Transcellular transport is not required for transmucosal bacterial passage across the intestinal membrane ex vivo
A thermal injury-induced circulating factor(s) compromises intestinal cell morphology, proliferation, and migration
Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens
CRISPR & Staphylococcus
CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.