Bacterial vaginosis: Standard treatments and alternative strategies.

International Journal of Pharmaceutics
Mariana TomásRita Palmeira-de-Oliveira

Abstract

Bacterial vaginosis (BV) affects many women and has a high influence on their self-esteem, being associated with huge discomfort and changes in the routines, especially the sexual life. International guidelines recommend the administration of metronidazole, clindamycin or tinidazole orally or intravaginally as the standard treatment. However, the treatment with these antibiotics is associated with high levels of failure and recurrence rates. These may be associated with antibiotic resistance, the inability to eradicate the polymicrobial biofilms, and failure to reestablish acidic pH and the lactobacillus-dominated commensal flora. Therefore, it is emergent to study alternative strategies to replace or to be combined with standard therapies in order to prevent and treat BV more efficiently. Alternative strategies may include antimicrobial substances (other antimicrobials, antiseptics and natural compounds) or substances that aim to reestablish the physiologic vaginal environment (probiotics, prebiotics and acidifying agents) while improving the local immunity response. Besides, the development of formulation strategies and new dosage forms and drug delivery systems can improve treatment efficacy and overcome some limitations ass...Continue Reading

Citations

Jan 10, 2021·International Journal of Molecular Sciences·Giovanna BatoniSemih Esin
Apr 17, 2021·Phytotherapy Research : PTR·Haiyue ZhaoLan Shen
Apr 26, 2021·International Journal of Pharmaceutics·Gabriela Corrêa CarvalhoMarlus Chorilli
Aug 17, 2021·Bioscience Reports·Karen GrewalPhillip R Bennett

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