PMID: 11904618Mar 21, 2002Paper

Bacterially induced preterm labor in the mouse does not require maternal interleukin-1 signaling

American Journal of Obstetrics and Gynecology
Emmet HirschRyan Blanchard

Abstract

We tested the hypothesis that intrauterine bacterial inoculation induces labor via expression of the inflammatory cytokine interleukin-1 (IL-1) in a murine model. Pregnant mice on day 14.5 of a 19-20 day gestation were inoculated with killed Escherichia coli or sterile media into either (a) the right uterine horn, (b) the right uterine horn following its surgical isolation from the contralateral horn and cervix, or (c) the kidney. Cytokine levels in gestational tissues and maternal serum were determined by use of enzyme-linked immunosorbent assay (ELISA). In a separate experiment, bacterially induced preterm delivery was compared between mice lacking a functional IL-1 receptor and wild-type control litter mates. Killed E coli induced delivery within 48 hours with similar dose-response curves regardless of inoculation site (intact uterine horn, isolated uterine horn, or kidney). Bacterial inoculation of an isolated right horn caused dramatic increases in local expression of IL-1 and IL-6. However, delivery occurred from the uninjected horn without corresponding upregulation of cytokines, with the exception of a modest rise within fetal membranes. Mice lacking a functional IL-1 receptor were no different from wild-type mice in th...Continue Reading

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Citations

Apr 16, 2011·Reproductive Sciences·Clare A BerrySuhas G Kallapur
Oct 28, 2011·Reproductive Sciences·Matthew W KempJohn P Newnham
Oct 20, 2015·American Journal of Obstetrics and Gynecology·Yana FilipovichEmmet Hirsch
Dec 24, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·E PetitD Subtil
Sep 6, 2011·Clinics in Perinatology·Jamie A BastekMichal A Elovitz
Dec 20, 2015·Cytokine & Growth Factor Reviews·Mathieu Nadeau-ValléeSylvain Chemtob
Apr 25, 2008·Journal of Reproductive Immunology·C HolmgrenR Silver
Jul 29, 2015·American Journal of Obstetrics and Gynecology·Yana FilipovichEmmet Hirsch
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Chong Jai KimYeon Mee Kim
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Qing YangAshima Madan
Mar 10, 2015·The American Journal of Pathology·Sara F RinaldiSarah J Stock
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·R RomeroM Mazor
Jan 6, 2009·American Journal of Obstetrics and Gynecology·Yana FilipovichEmmet Hirsch
May 2, 2006·American Journal of Obstetrics and Gynecology·Emmet HirschMala Mahendroo
Mar 24, 2005·Journal of the Society for Gynecologic Investigation·Emmet Hirsch, Hao Wang
Oct 6, 2005·Journal of the Society for Gynecologic Investigation·Roberto RomeroJimmy Espinoza
Oct 6, 2005·Journal of the Society for Gynecologic Investigation·Kazuaki Yoshimura, Emmet Hirsch
Jun 29, 2010·Reproductive Sciences·Matthew W KempSuhas G Kallapur
Mar 29, 2018·Biology of Reproduction·Varkha AgrawalEmmet Hirsch
May 5, 2005·American Journal of Physiology. Endocrinology and Metabolism·Bryan F MitchellJana M Mitchell
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan F Mitchell, Michael J Taggart
Dec 3, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschLami Yeo
Sep 8, 2011·Expert Review of Clinical Immunology·Sara F RinaldiJane E Norman
Apr 3, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Viral G JainLouis J Muglia
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Apr 26, 2021·Advanced Drug Delivery Reviews·Hannah C ZierdenLaura M Ensign

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