Bactericidal action of an average dose of erythromycin in the bronchi

Current Medical Research and Opinion
F FraschiniG Scarpazza

Abstract

A study was carried out to establish whether erythromycin stearate was bacteriostatic or bactericidal at the concentrations reached in the bronchial secretion. Twenty-two patients suffering from an acute attack of chronic bronchitis, sustained by streptococci, diplococci, staphylococci or H. influenzae sensitive to erythromycin, were treated with 1500 mg erythromycin per day until symptoms regressed, usually within 3 to 5 days. The results showed that after treatment there was a dramatic reduction in the number of bacterial colonies cultured from the bronchial secretion and marked changes in bacterial morphology were seen using electron microscopy. Further evidence of bactericidal activity was provided by the rapid clinical response of the patients.

References

Jan 1, 1981·Current Medical Research and Opinion·F FraschiniG Scarpazza
Jan 1, 1985·Current Medical Research and Opinion·M FalchiF Fraschini
Apr 1, 1985·Mayo Clinic Proceedings·J A Washington, W R Wilson
Jan 1, 1986·The Journal of International Medical Research·E ConciaR Braschi

Citations

Apr 1, 1972·Journal of General Microbiology·D Greenwood, F O'Grady
Oct 22, 1969·Biochemical and Biophysical Research Communications·K IgarashiA Kaji

Related Concepts

Diplococci
Bronchitis, Chronic
Erythromycin
Haemophilus influenzae
Erythromycin stearate
Science of Morphology
Bronchi
Staphylococcal Infections
Bactericidal Activity
Bronchitis

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