Bactericidal activity of BAL9141, a novel parenteral cephalosporin against contemporary Gram-positive and Gram-negative isolates

Diagnostic Microbiology and Infectious Disease
Lalitagauri M DeshpandeRonald N Jones

Abstract

BAL9141, the active principle of prodrug BAL5788, is a parenteral cephalosporin active against oxacillin-resistant Staphylococcus aureus. Previous studies have reported the cidal action of BAL9141 towards limited numbers of isolates by time-kill methods. We tested >100 staphylococci, streptococci, and Gram-negative isolates by broth microdilution methods to determine the antibacterial activity of BAL9141 and to compare minimum inhibitory concentrations (MICs) with minimum bactericidal concentrations (MBCs). Among the 53 staphylococcal isolates, all but one (98%) had a, MBC:MIC ratio < or =2. Forty-five percent (five strains) of the penicillin-nonsusceptible Streptococcus pneumoniae isolates had an MBC:MIC ratio >4. Among 22 Enterobacteriaceae, 73% of isolates had MBC:MIC ratios of 2 or less; three strains with ratios greater than 4 were Serratia marcescens. BAL9141 displayed a predominant bactericidal activity against the majority of Gram-positive and -negative species, including resistant subsets, making it an attractive candidate for further development.

References

Dec 4, 2002·The Journal of Antimicrobial Chemotherapy·Ronald N JonesDouglas J Biedenbach
Oct 18, 2003·The Journal of Antimicrobial Chemotherapy·Bulent BozdoganPeter C Appelbaum
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L M Deshpande, R N Jones
Feb 6, 2004·Diagnostic Microbiology and Infectious Disease·Nicolas C IssaRobin Patel

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Citations

Nov 6, 2010·The Journal of Antimicrobial Chemotherapy·Gian M Rossolini CLASS Study Group
Mar 28, 2007·Antimicrobial Agents and Chemotherapy·Stefanie HellerStuart Shapiro
Sep 20, 2006·Antimicrobial Agents and Chemotherapy·Ellie J C GoldsteinHelen T Fernandez
Mar 28, 2007·Antimicrobial Agents and Chemotherapy·Thomas P LodiseGeorge L Drusano
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Christof von EiffGeorg Peters
Jan 1, 2010·Infection and Drug Resistance·César Bustos, Jose L Del Pozo
Sep 9, 2009·Expert Review of Anti-infective Therapy·Patricia L Schirmer, Stanley C Deresinski
Jan 25, 2007·Expert Opinion on Investigational Drugs·Garyphallia Poulakou, Helen Giamarellou
Jan 31, 2008·Expert Opinion on Investigational Drugs·Garyphallia Poulakou, Helen Giamarellou
Jul 30, 2005·Expert Opinion on Investigational Drugs·Holly L Hoffman-RobertsIsaac F Mitropoulos
Mar 1, 2011·Diagnostic Microbiology and Infectious Disease·Andrew WalktyUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA)
Apr 4, 2008·Diagnostic Microbiology and Infectious Disease·Stanley C Deresinski
Apr 4, 2008·Diagnostic Microbiology and Infectious Disease·Thomas P LodiseRonald N Jones
Nov 18, 2015·Future Microbiology·Thomas W L Scheeren
Jan 8, 2015·Natural Product Research·Paul-Keilah LungaDonatien Gatsing
May 3, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Moreillon
May 15, 2008·The Annals of Pharmacotherapy·Shawn D Anderson, John G Gums
Feb 9, 2017·BMC Complementary and Alternative Medicine·Guy Sedar Singor NjatengJules-Roger Kuiate

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