Bactericidal activity of telavancin, vancomycin and metronidazole against Clostridium difficile

Anaerobe
Ellie J C GoldsteinYumi A Warren

Abstract

We compared the time-kill activities of telavancin, vancomycin and metronidazole at concentrations of 2 times, 4 times, and 8 times their respective MICs against five Clostridium difficile strains including REA type BI, using inocula that contained predominantly either vegetative cells or spores. Telavancin MICs (0.125-0.25 microg/ml) were 2-8-fold lower than those of vancomycin. Telavancin was bacteriostatic, reducing the inoculum by 1-2.5 log(10) after 24 h. No major differences occurred with the different inoculum forms or the REA types. Although telavancin MICs were 2-8 times lower than vancomycin, both demonstrated similar bacteriostatic activity against C. difficile while metronidazole was bactericidal.

References

Jun 30, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fred A ZarMelinda B Davis
May 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wafa N Al-NassirCurtis J Donskey
Jul 25, 2008·Journal of Clinical Microbiology·T PeláezE Bouza
Aug 12, 2008·The Journal of Antimicrobial Chemotherapy·Simon D BainesMark H Wilcox

Citations

Jan 9, 2014·PloS One·Patrick M ChongCanadian Nosocomial Infection Surveillance Program (CNISP)
Apr 27, 2012·Expert Opinion on Pharmacotherapy·Luciano SilvestriAndy J Petros

Related Concepts

Telavancin
Aminoglycosides
Antibiotics
Bayer 5360
Fungus Drug Sensitivity Tests
AB-Vancomycin
Clostridium difficile (bacteria)
Metronidazole
Spores, Fungal
Vancomycin

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