Bactericidal and Virucidal Activity of Povidone-Iodine and Chlorhexidine Gluconate Cleansers in an In Vivo Hand Hygiene Clinical Simulation Study

Infectious Diseases and Therapy
Maren EggersStefan Müller

Abstract

Standard in vitro and in vivo tests help demonstrate efficacy of hand hygiene products; however, there is no standard in vivo test method for viruses. We investigated the bactericidal and virucidal efficacy of povidone-iodine (PVP-I) 7.5% scalp and skin cleanser, chlorhexidine gluconate (CHG) 4% hand cleanser and the reference hand wash (soft soap) in 15 healthy volunteers following European Standard EN1499 (hygienic hand wash test method for bacteria), which was adapted for virucidal testing. Separate test series were performed for bactericidal (Escherichia coli) and virucidal [murine norovirus (MNV)] testing. After pre-washing and artificial contamination of hands with test organisms, volunteers underwent testing with 3 and 5 mL of each product for contact times of 15, 30 and 60 s according to a Latin-square randomization. The number of test organisms released from fingertips into sampling fluids was assessed before and after hand washing and mean log10 reduction factor (RF) was calculated. RFs (test-reference) were compared using a Wilcoxon-Wilcox multiple comparisons test per EN1499; efficacy was concluded if p ≤ 0.01. PVP-I 7.5% and CHG 4% cleansers both passed EN1499 requirements against E. coli, with statistically signif...Continue Reading

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Citations

Apr 18, 2020·Journal of Dental Research·R IzzettiF Graziani
Aug 21, 2020·BMJ Open Ophthalmology·Magdalena EdingtonDavid Lockington
Jul 18, 2020·International Journal of Dentistry·Shashi Dadlani
Jun 25, 2020·Clinical Oral Investigations·David HerreraMariano Sanz
Aug 16, 2019·Infectious Diseases and Therapy·Maren Eggers
Jan 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Noelia Maldonado, Pilar Amo-Ochoa
Feb 3, 2021·Critical Reviews in Food Science and Nutrition·Fabio MasottiIvano De Noni
Oct 24, 2020·Journal of Water and Health·Mohammad Hussein Al-Sayah
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Jul 3, 2021·Biophysical Journal·Mateusz RzyckiSebastian Kraszewski
Sep 1, 2021·Journal of Biomaterials Science. Polymer Edition·Manisha MalaniJayabalan Nirmal
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Nov 30, 2021·Minerva Dental and Oral Science·Santosh K VermaDeepyanti Dubey
Dec 24, 2021·Scientific Reports·Maria D FerrerAlex Mira

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