Bactericidal capacity of newborn phagocytes against group B beta-hemolytic streptococci.

Infection and Immunity
I D BeckerR R Kretschmer

Abstract

The bactericidal capacity of mononuclear and polymorphonuclear phagocytes obtained from normal newborn infants and from healthy adults was evaluated in vitro, using two group B beta-hemolytic streptococci (GBBHS) serotypes (GBBHS-Ia-SS-615/28 and GBBHS-III-SS-620/50) and uniform opsonic conditions. No intertype differences in bacteriolysis of these two serotypes were observed among leukocytes from newborns or adults. As group, only polymorphonuclear phagocytes from newborns disclosed a significantly lower mean bactericidal capacity than their adult cellular counterpart, and only with respect to GBBHS-III-SS-620/50. On the other hand, 4 or 16 polymorphonuclear samples from newborns tested revealed significantly low bactericidal capacities against both GBBHS serotypes, and an additional sample revealed a bactericidal capacity against GBBHS-III-SS-620/50 alone. Interstrain variations in the intrinsic bactericidal capacity of polymorphonuclear phagocytes from newborns against GBBHS-III may exist, as suggested by a single observation made by using four clinical isolates of GBBHS-III. Such deviant phagocytic capacities of polymorphonuclear phagocytes from newborns may constitute an additional selective risk factor in the genesis of G...Continue Reading

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Citations

Apr 16, 1998·Immunology·P CornacchioneP Marconi
May 26, 1998·Scandinavian Journal of Immunology·E RosatiP Marconi
Mar 22, 2013·Biochemical Society Transactions·Leanne M Smith, Robin C May
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Jun 14, 2013·Clinical & Developmental Immunology·Koen Vanden DriesscheKevin B Urdahl
Oct 2, 2002·Molecular Microbiology·Philippe GlaserFrank Kunst
Aug 1, 1994·FEMS Immunology and Medical Microbiology·L ScaringiP Marconi
Jul 1, 1996·Infection and Immunity·P Valentin-WeigandG S Chhatwal
Jun 1, 1983·Current Problems in Pediatrics·K L CatesM Ballow

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