Bactericidal effect of intravitreal levofloxacin in an experimental model of endophthalmitis

The British Journal of Ophthalmology
C FerrerJ L Alió

Abstract

To evaluate the efficacy of intravitreal 1.5% levofloxacin versus combined treatment with vancomycin and ceftazidime in an experimental model of bacterial endophthalmitis. The right eye of 75 New Zealand White rabbits was inoculated in the vitreous cavity with strains of Staphylococcus epidermidis, Staphylococcus aureus or Pseudomonas aeruginosa. The study evaluated treatment with 1.5% levofloxacin compared with 1% vancomycin plus 2.2% ceftazidime, and a control group. At 24 h after treatment, 100 microl vitreous and aqueous humor were harvested, and the number of colony-forming units (CFU) per ml was determined. The microbiological status of the vitreous and aqueous humor samples was tested at day 2, 3, 5 and 8. The Peyman classification was used to assess the severity of endophthalmitis. For the S. epidermidis endophthalmitis model, levofloxacin treatment produced an approximately 3 log decrease in CFU/ml of vitreous relative to that in untreated eyes (p = 0.023), whereas vancomycin plus ceftazidime produced a 5 log reduction in CFU/ml (p = 0.023). However, in the S. aureus model, levofloxacin treatment produced an approximately 4 log reduction in CFU/ml, whereas vancomycin plus ceftazidime produced an approximately 2 log red...Continue Reading

Citations

Oct 28, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhaoxin JiangQianying Gao
Jan 26, 2012·International Journal of Nanomedicine·Zhaoxin JiangQianying Gao
Dec 12, 2012·Journal of Cataract and Refractive Surgery·Bingsheng LouYizhi Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.