PMID: 2124125Aug 1, 1990Paper

Bactericidal efficacy of 5 per cent povidone iodine cream in Pseudomonas aeruginosa burn wound infection

Burns : Journal of the International Society for Burn Injuries
P M De WetS Cywes

Abstract

A new topical antiseptic agent, 5 per cent polyvinylpyrrolidone-iodine (PVP-I) cream, with altered physicochemical properties, incorporated in a different carrier base has proved in vivo to be more effective in controlling burn wound infections than 10 per cent PVP-I ointment. Important biodynamic properties of the new formulation have not, however, been elucidated in vivo. Hence the need for a controlled study to evaluate the bioavailability of the active component after penetration through burn eschar; the bactericidal efficacy of the cream and determination of the bactericidal time of the cream in comparison with 10 per cent PVP-I ointment. A modified Walker burn wound model was used to define the rate of trans-eschar penetration, biodynamic availability and bactericidal efficacy of 5 per cent povidone iodine cream in established Pseudomonas aeruginosa burn wound infection. In vitro penetration confirmed the effective diffusion of PVP-I cream through 1.5 mm eschar within 6 h. A single topical application of PVP-I cream resulted in a 98.8 per cent (6.088 x 10(9) c.f.u./g of tissue to 7.367 x 10(7) c.f.u./g of tissue) reduction in intra-eschar viable organisms within 18 h after application. A second topical application of PVP-...Continue Reading

References

Feb 1, 1980·The Journal of Trauma·J L HuntC R Baxter
Aug 1, 1964·Annals of Surgery·H L WALKERG L RAULSTON

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Citations

Apr 20, 2001·Burns : Journal of the International Society for Burn Injuries·D UlrichN Pallua
Aug 24, 1999·Fundamental & Clinical Pharmacology·I MargaretK Jamil
Dec 29, 2010·Indian Journal of Pharmaceutical Sciences·Pallavi L Pawar, Bela M Nabar
Sep 19, 2006·Acta Cirúrgica Brasileira·Armando José d'AcamporaRicardo Tramonte
Oct 1, 1991·Clinics in Dermatology·L Andreassi, L Flori

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