Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus

Future Microbiology
Patricia LetradoPedro García

Abstract

To test the synergistic effect of Cpl-711 endolysin and antibiotics for antipneumococcal activity. A combination of Cpl-711 and different antibiotics (amoxicillin, cefotaxime, levofloxacin and vancomycin) was tested in a checkerboard assay against several multidrug-resistant Streptococcus pneumoniae strains. Mouse and zebrafish models of pneumococcal sepsis were used to confirm the in vitro data. The activity of Cpl-711 combined with amoxicillin or cefotaxime was synergistic in the bactericidal effect against a serotype 23F multiresistant clinical isolate of S. pneumoniae. Synergy between Cpl-711 and cefotaxime was validated using both mouse and zebrafish models. Combination of Cpl-711 and cefotaxime may help in the treatment of diseases caused by multiresistant pneumococcal strains.

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Citations

Sep 9, 2019·Folia Microbiologica·Shikha MalikKiran Nehra
Jun 25, 2019·Frontiers in Microbiology·Roberto Vázquez, Pedro García
Nov 22, 2018·Frontiers in Immunology·Roberto VázquezPedro García
Nov 13, 2019·International Journal of Antimicrobial Agents·Vijay Singh GondilSanjay Chhibber
Feb 3, 2021·Antibiotics·Fatma AbdelrahmanAyman El-Shibiny
Feb 3, 2021·Current Opinion in Biotechnology·Sara B LindenDaniel C Nelson
Aug 28, 2021·Antibiotics·Lucía FernándezPilar García
Jan 4, 2022·ACS Infectious Diseases·Prasanth ManoharSebastian Leptihn

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