Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients.

Antimicrobial Agents and Chemotherapy
H G de Vries-HospersH K van Saene

Abstract

We describe the bacteriological results of a controlled clinical trial of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Selective elimination of Enterobacteriaceae and Pseudomonadaceae species was accomplished by the oral administration of nalidixic acid, co-trimoxazole, or polymyxin. Yeasts were eliminated selectively by amphotericin B or nystatin treatment. The drugs used in this study were chosen because of their capacities to selectively eliminate gram-negative rods and yeast without affecting the anaerobic part of the gut flora which is responsible for colonization resistance. Compared with the control group, the selectively decontaminated patients had significantly fewer (P less than 0.0005) gram-negative rods or yeasts or both in their throat swab cultures and in their feces. This reduction may explain the clinical effectiveness of selective decontamination.

References

Jun 1, 1978·Antimicrobial Agents and Chemotherapy·D M HahnP H Wiernik
Mar 26, 1977·British Medical Journal·H F Guiot, R Furth
Jan 1, 1979·The American Journal of Medicine·J R KoranskyV R Dowell
Jan 1, 1975·Acta Clinica Belgica·J KlasterskyL Debusscher
Oct 1, 1975·Journal of Clinical Microbiology·D A ButlerT L Gavan
Apr 1, 1974·The Journal of Hygiene·D van der Waaij, J M Berghuis-de Vries
Dec 1, 1972·The Journal of Hygiene·D van der WaaijJ E Lekkerkerk
Dec 1, 1972·The Journal of Hygiene·D van der WaaijJ M Vossen
Jun 1, 1974·The Journal of Hygiene·D van der Waaij, J M Berghuis
Jun 1, 1972·The Journal of Hygiene·D van der Waaij Lekkerkerk-van der Wees
Sep 1, 1971·The Journal of Hygiene·D van der Waaij Lekkerkerk Lekkerkerk-v
Jun 1, 1971·The American Journal of Medicine·J M Felner, V R Dowell
Jul 21, 1969·JAMA : the Journal of the American Medical Association·R J Alpern, V R Dowell
Jun 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D T SleijferH K van Saene
Mar 1, 1980·Journal of General Microbiology·G W WellingH M Kennis

❮ Previous
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Citations

Dec 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A DawC T Keane
Jan 1, 1984·Antonie van Leeuwenhoek·M P Hazenberg, A M Pennock-Schröder
Jan 1, 1979·Folia Microbiologica·J Sterzl
May 1, 1987·The Journal of Surgical Research·E A Deitch, R M Bridges
Jun 1, 1990·Burns : Journal of the International Society for Burn Injuries·W L MansonH J Klasen
May 1, 1994·European Journal of Cancer. Part B, Oral Oncology·F MeunierP Autier
Oct 9, 1998·Journal of Hepatology·P Ginès, M Navasa
Aug 1, 1984·The Journal of Hygiene·M P HazenbergJ P Van de Merwe
Jul 8, 1982·The New England Journal of Medicine·P A Mackowiak
Dec 1, 1983·Antimicrobial Agents and Chemotherapy·H L MuytjensD van der Waaij
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·J R WingardR Saral
Jan 30, 1993·BMJ : British Medical Journal·S W Atkinson, D J Bihari
Jul 1, 1989·The Journal of Clinical Investigation·E A DeitchR D Berg
Nov 28, 2012·Antimicrobial Resistance and Infection Control·Jean Carlet
Jan 1, 1990·Intensive Care Medicine·D van der WaaijH G de Vries-Hospers
Jun 1, 1983·Antonie van Leeuwenhoek·M P HazenbergJ P Van de Merwe
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·A G Toorop-Bouma, D van der Waaij
Jul 1, 1985·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·D van der WaaijH O Nieweg
Mar 22, 2007·Alimentary Pharmacology & Therapeutics·M GattJ MacFie
Nov 1, 1988·The Journal of Hospital Infection·M A DawC T Keane
Apr 1, 1992·Burns : Journal of the International Society for Burn Injuries·W L MansonA Olieman
Jun 3, 2009·FEMS Immunology and Medical Microbiology·Mirjam Kooistra-SmidHenri Verbrugh
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A. BuzynUNKNOWN The CLIOH group
Feb 19, 1981·The New England Journal of Medicine·W M Nauseef, D G Maki
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GinésJ M Salmerón
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Hoefs
Jul 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·S N Aker, C L Cheney
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Feb 26, 2020·International Journal of Environmental Research and Public Health·Truls Gjestland

❮ Previous
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