Bacteriological profile of neonatal septicemia and antibiotic susceptibility pattern of the isolates

Journal of Natural Science, Biology, and Medicine
P JyothiPeerapur V Basavaraj

Abstract

Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in the first four weeks of life and is one of the four leading causes of neonatal mortality and morbidity in India. To isolate and identify the bacterial etiologic agents responsible for neonatal sepsis and to determine the susceptibility pattern of isolates in a tertiary care hospital in North Karnataka. Six hundred eighty-three blood samples were collected and processed from patients in accordance with standard protocols. Antibiotic susceptibility of the isolates was done by disc diffusion method according to National Committee for Clinical Laboratory Standards (NCCLS) recommendations. Blood culture reports were positive in 19.2% cases. Among the culture positive cases, there were 65.5% males and 34.5% females. Early-onset sepsis was present in 74.8% and late-onset sepsis was observed in 25.2% of the cases. Best overall sensitivity among Gram-negative isolates was to imipenem (93%), followed by amikacin (52%) and netilmicin (41%). Gram-positive isolates had sensitivity of 91% to linezolid, 68% to tetracycline, 64% to piperacillin/tazobactam erythromycin, and 52% to ciprofloxacin. Gram-negative organisms (Klebsiella, Acinetoba...Continue Reading

Citations

Feb 10, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mamta LambaRakesh Kumar Maheshwari
Mar 22, 2016·The Indian Journal of Medical Research·Anusha RohitIndrani Karunasagar
Mar 4, 2014·International Journal of Pediatric Otorhinolaryngology·Fadlullah AksoyÖnder Hüseyinbas
Apr 6, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Pricilla Dias Moura de MatosKátia Regina Netto Dos Santos
Feb 6, 2017·Therapeutic Advances in Infectious Disease·Nikita VasudevaPreeti Shrivastava
Feb 15, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet MutluGürdal Yılmaz
Jul 11, 2019·Open Forum Infectious Diseases·Ruvandhi R NathavitharanaRocio M Hurtado
Sep 13, 2019·Fetal and Pediatric Pathology·Birol Karabulut, Baran Cengiz Arcagok
Aug 17, 2018·Journal of Pathogens·Obiora Shedrach EjioforAngus Nnamdi Oli
Apr 23, 2021·Journal of Pediatric Intensive Care·Birol Karabulut, Silem Ozdem Alatas
Jun 29, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Swati MahichVikas Gautam

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Statistical Package for Social Sciences ( SPSS )

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