Bacteriological profile of ventilator-associated pneumonia in a tertiary care hospital

Indian Journal of Pathology & Microbiology
Somi PatroNirupama Chayani

Abstract

Ventilator-associated pneumonia (VAP) is the most frequent intensive care unit (ICU)-acquired infection. The etiology of VAP and their antimicrobial susceptibility pattern varies with different patient populations and types of ICUs. An observational cross-sectional study was performed over a period of 2 years in a tertiary care hospital to determine the various etiological agents causing VAP and to detect the presence of multidrug-resistant (MDR) pathogens in these VAP patients. Combination disk method, Modified Hodge test, ethylenediaminetetraacetic acid disk synergy test, and AmpC disk test were performed for the detection of extended-spectrum beta-lactamase (ESBL), carbapenemases, metallo-beta-lactamases (MBL), and AmpC beta-lactamases, respectively. The prevalence of VAP was 35%. Enterobacteriaceae (66.66%) and Staphylococcus aureus (20%) were common in early-onset VAP, while nonfermenters (50%) and Enterobacteriaceae (40.61%) were predominant from late-onset VAP. Nearly 60.87% of the bacterial pathogens were MDR. ESBL was produced by 21.74% of Enterobacteriaceae. AmpC β-lactamase was positive in 35.29% nonfermenters and 26.08% Enterobacteriaceae. MBL was positive in 17.64% nonfermenters and 17.39% Enterobacteriaceae. Among...Continue Reading

References

Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·J RelloR Rodriguez-Roisin
Mar 21, 1998·JAMA : the Journal of the American Medical Association·D CookC Brun-Buisson
Sep 12, 1998·Annals of Internal Medicine·D J CookC Brun-Buisson
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Jean Chastre, Jean-Yves Fagon
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Muriel FartoukhChristian Brun-Buisson
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John QualeRenuka Heddurshetti
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
May 12, 2006·Indian Journal of Medical Microbiology·T RajasekharV Lakshmi
Aug 11, 2006·Chest·Ilana Porzecanski, David L Bowton
Dec 14, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J L KutiD P Nicolau
May 5, 2010·Journal of Infection in Developing Countries·Noyal Mariya JosephSubhash Chandra Parija

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Citations

Feb 28, 2019·Frontiers in Pharmacology·Chao-Yang WangXue-Qun Ren
Aug 3, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Alessio StrazzullaSylvain Diamantis
May 31, 2019·Frontiers in Pharmacology·Diling WuYanjun Zhong
Dec 4, 2020·Journal of Laboratory Physicians·Venkatesh Sudharsan VaithiyamAshutosh Biswas
Nov 18, 2021·Indian Journal of Medical Microbiology·Tanu SinghalSubhash Todi

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