Bacteriological relevance of linezolid vs. vancomycin in postoperative empirical treatment of osteoarticular infections: a retrospective single-center study

International Journal of Antimicrobial Agents
E TakoudjuNantes Bone and Joint Infections Study Group

Abstract

In 2015, our center replaced vancomycin with linezolid for the postoperative empirical treatment of osteoarticular infections (OAI). To assess the bacteriological relevance of linezolid for orthopedic postoperative probabilistic antibiotic therapy. Analysis of an observational cohort of patients empirically treated with a combination of linezolid and piperacillin/tazobactam during the immediate postoperative stage for an OAI between July 1st 2015 and July 1st 2016, in a French reference center. Seventy-seven of 126 patients who received a probabilistic postoperative combination of linezolid with piperacillin/tazobactam had microbiological proof of infection. Sixty-six of 77 OAI involved material, including an osteosynthesis in 45 cases (68%) and prosthesis in 21 cases (32%). Infection was due to Gram-positive bacteria in 62 cases (80.5%), mostly S. aureus (n=32, 41.6%), and S. epidermidis (n=14, 18.2%) accounting for 74.2% of Gram-positive bacteria. Among 14 OAI due to S. epidermidis, 11 (78.6%) were due to methicillin-resistant strains. All the S. aureus and S. epidermidis strains were susceptible to linezolid (MICs ≤ 4 mg/L), except in one patient previously treated with linezolid who was infected with a linezolid-resistant S...Continue Reading

Citations

Oct 28, 2019·Therapeutic Drug Monitoring·Gauri G RaoUNKNOWN IATDMCT Antimicrobial Scientific Committee
Jun 17, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Luc DerocheUNKNOWN and the CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest) Study Group
Sep 29, 2020·Journal of Bone and Joint Infection·Christoph TheilBurkhard Möllenbeck

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