Bacteriolytic therapy of experimental pancreatic carcinoma.

World Journal of Gastroenterology : WJG
Claudia MaletzkiMichael Linnebacher

Abstract

To investigate the effectiveness of Clostridium novyi (C. novyi)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic, immunocompetent Panc02/C57Bl/6 model. C. novyi-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different sizes. Systemic immune responses in peripheral blood and spleen were examined by flow cytometry. Supplementary, cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. Application of spores identified, that (1) small tumors (< 150 mm(3)) were completely unaffected (n = 10); (2) very large tumors (> 450 mm(3)) responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n = 6); and (3) an optimal treatment window exists for tumors of approximately 250 mm(3) (n = 21). In this latter group, all tumor-bearing animals had complete tumor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed (tumor volume at day 28: 197.8 +/- 87.3 mm(3) vs 500.1 +/- 50.9 mm(3), P < 0.05). These effects were accompanied by system...Continue Reading

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Citations

Dec 23, 2011·Langenbeck's Archives of Surgery·Michael LinnebacherErnst Klar
Dec 29, 2013·Clinical & Developmental Immunology·Saskia StierMichael Linnebacher
Mar 14, 2013·Journal of Drug Targeting·Van Anh Thi NguyenSimon M Cutting
Jun 5, 2013·Human Vaccines & Immunotherapeutics·Sun-Young ChangHyun-Jeong Ko
Oct 20, 2018·Applied Microbiology and Biotechnology·Piyush BaindaraVishakha Grover
Jun 22, 2019·FEMS Microbiology Letters·Sergio Rius-RocabertEstanislao Nistal-Villan

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