PMID: 6159450Nov 1, 1980Paper

Bacteriophage control of antiphagocytic determinants in group A streptococci

The Journal of Experimental Medicine
J G Spanier, P P Cleary

Abstract

At least two genes have been shown to be required for the expression of the antiphagocytic M protein molecule in group A streptococci. Evidence for phage involvement in the expression of M protein is that: (a) M- cultures of bacteria can be converted to the M+ state (resistant to phagocytosis) upon lysogenization with appropriate bacteriophages; (b) without those bacteriophages the M- recipient culture could not be detected to revert to the M+ state, even under our most stringent selective conditions; and (c) stable M+ lysogens cured of their bacteriophages returned to the M- state. Immunochemical analysis of lysogenically converted M+ strains demonstrated that they contain precipitating and antiphagocytic determinants of the parental M-76 strain (CS110) rather than M-12 determinants expressed by the phage donor strain. This information strongly suggests that the M- strain CS112 possesses the structural gene for M protein, but that it remains predominantly unexpressed. Quantitation of the M antigen produced by these strains supports the observation that the M- phage-recipient strain possesses a small amount of extractable M antigen and that phage activates its synthesis by some unknown mechanism. Various possibilities to accoun...Continue Reading

References

Apr 8, 1977·Science·J ZiegM Simon
Nov 1, 1971·The Journal of Experimental Medicine·J RottaH Lackland
Jan 1, 1974·Annual Review of Microbiology·L Barksdale, S B Arden
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Citations

Jan 1, 1988·Folia Microbiologica·L E RavdonikasA A Totolian
Jan 9, 2008·The Journal of Infectious Diseases·Ivo VojtekEmmanuelle Charpentier
Jul 16, 2002·Infection and Immunity·Patrick L Wagner, Matthew K Waldor
Jun 5, 2007·Trends in Microbiology·Vincent A Fischetti
Oct 30, 1983·Virology·J G Spanier, P P Cleary
Jul 24, 2013·Infection and Immunity·Nadine DaouCaroline A Genco
Nov 1, 1985·Journal of Bacteriology·J G Spanier, P P Cleary
Dec 1, 1987·Journal of Bacteriology·J C RobbinsP P Cleary

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