Abstract
The gut microbiota has been recognized as a critical regulator of human health, and novel interventions to selectively modulate the microbiota are actively being sought. Bacteriophages (bacterial viruses) have the potential to selectively eliminate specific detrimental microbes while enhancing beneficial microbe populations. The Bacteriophage for Gastrointestinal Health (PHAGE) study aimed to determine the safety and tolerability of supplemental bacteriophage consumption in a population of healthy adults with mild to moderate gastrointestinal distress. The PHAGE study was a randomized, double-blind, placebo-controlled crossover intervention. Healthy adults with self-reported gastrointestinal distress were recruited and asked to consume one 15-mg capsule containing 4 strains of bacteriophages (LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, and LL12-Myoviridae) and a placebo, each for 28 days. Participants were randomly assigned to the starting treatment, which was followed by a 2-week washout period before they began the second arm of the intervention. Primary outcome measures included a comprehensive metabolic panel and gastrointestinal health questionnaire. In addition, samples were collected for future analysis of several...Continue Reading
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