Bacteriophage migration via nematode vectors: host-parasite-consumer interactions in laboratory microcosms

Applied and Environmental Microbiology
John J DennehyPaul E Turner

Abstract

Pathogens vectored by nematodes pose serious agricultural, economic, and health threats; however, little is known of the ecological and evolutionary aspects of pathogen transmission by nematodes. Here we describe a novel model system with two trophic levels, bacteriophages and nematodes, each of which competes for bacteria. We demonstrate for the first time that nematodes are capable of transmitting phages between spatially distinct patches of bacteria. This model system has considerable advantages, including the ease of maintenance and manipulation at the laboratory bench, the ability to observe many generations in short periods, and the capacity to freeze evolved strains for later comparison to their ancestors. More generally, experimental studies of complex multispecies interactions, host-pathogen coevolution, disease dynamics, and the evolution of virulence may benefit from this model system because current models (e.g., chickens, mosquitoes, and malaria parasites) are costly to maintain, are difficult to manipulate, and require considerable space. Our initial explorations centered on independently assessing the impacts of nematode, bacterium, and phage population densities on virus migration between host patches. Our resul...Continue Reading

References

Dec 5, 2000·Genetics·P E Turner, S F Elena
Jun 21, 2002·The Journal of General Virology·Evangelos VelliosStuart A MacFarlane
Aug 9, 2002·Theoretical Population Biology·Roger W Hendrix
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shah M FaruqueG Balakrish Nair
Apr 18, 2003·The American Naturalist·Paul E Turner, Lin Chao
May 31, 2003·Nature Reviews. Genetics·Santiago F Elena, Richard E Lenski
Oct 2, 2003·Emerging Infectious Diseases·Shah M FaruqueDavid A Sack
Dec 12, 2003·American Journal of Respiratory and Critical Care Medicine·Kennedy F Shortridge
Jul 9, 2004·Genetics·Christina L Burch, Lin Chao
Nov 13, 2004·Proceedings. Biological Sciences·John J Dennehy, Paul E Turner
May 5, 2006·The American Naturalist·John J DennehyPaul E Turner

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Citations

Oct 22, 2010·Biology Letters·Simon FellousOliver Kaltz
Jul 22, 2008·Canadian Journal of Microbiology·Françoise BichaiBenoit Barbeau
Jan 17, 2014·Proceedings. Biological Sciences·Jeremy C Gray, Asher D Cutter
May 8, 2008·The Journal of Eukaryotic Microbiology·Agnes A AkunyiliCraig T Van Bell
May 10, 2017·Genetics·Hinrich Schulenburg, Marie-Anne Félix

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