Bacteriophage therapy of Salmonella enterica: a fresh appraisal of bacteriophage therapy

The Journal of Infectious Diseases
R CapparelliD Iannelli

Abstract

The most serious criticisms leveled at bacteriophage therapy are as follows: phages induce neutralizing antibodies, phages are active only when administered shortly after bacterial infection, and phage-resistant bacteria emerge rapidly in the course of therapy. Phages lytic for several Salmonella enterica serovars were isolated by means of standard protocols from feces of patients with gastroenteritis. Growth of S. enterica serovar Paratyphi B (Salp572(phi1S)) in the presence of phage phi1 (selected from among 8 phages for its larger host range) provided a phage phi1-resistant bacterial strain (Salp572(phi1R)). The properties of the Salp572(phi1S) and Salp572(phi1R) strains and of phage phi1 were studied in a mouse model of experimental infection. Phages induced nonneutralizing antibodies and were active 2 weeks after experimental infection of mice; phage-resistant bacteria were avirulent and short lived in vivo. More importantly, phage-resistant bacteria were excellent vaccines, protecting against lethal doses of heterologous S. enterica serovars. Phage therapy effectiveness has not yet been properly assessed.

Citations

Dec 29, 2011·The Journal of Microbiology·Birendra R TiwariJungmin Kim
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Cesar O FloresJoshua S Weitz
Aug 23, 2011·Foodborne Pathogens and Disease·Anthea C SaezPaul D Ebner
Jul 5, 2013·Acta Biomaterialia·Rebecca FarrSeung-Wuk Lee
Dec 19, 2012·Trends in Microbiology·Joshua S WeitzMichael E Hochberg
Mar 4, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jenny Fernebro
Mar 25, 2014·International Journal of Medical Microbiology : IJMM·Abhishek JaiswalBanwarilal Sarkar
Jun 22, 2011·Biotechnology Advances·Zahra Moradpour, Abdollah Ghasemian
Feb 16, 2012·Bacteriophage·Catherine Loc-Carrillo, Stephen T Abedon
Jul 3, 2013·Bacteriophage·Anni-Maria Ormälä, Matti Jalasvuori
Aug 23, 2016·Future Microbiology·Benjamin K ChanPaul E Turner
May 13, 2017·Médecine sciences : M/S·Nicolas Dufour, Laurent Debarbieux
Sep 20, 2016·Journal of Oral Microbiology·Leron KhalifaRonen Hazan
Nov 30, 2016·Current Microbiology·Agata Anna CisekZbigniew Wyżewski
Feb 25, 2020·Critical Reviews in Microbiology·Luís D R MeloJoana Azeredo
Jun 4, 2020·Antibiotics·Elina LaantoLotta-Riina Sundberg
Feb 11, 2015·Virologica Sinica·Youqiang XuChi Cheng
Nov 2, 2019·Microbiology and Molecular Biology Reviews : MMBR·Krystyna Dąbrowska, Stephen T Abedon
Jun 16, 2017·Annual Review of Microbiology·Brittany B Lewis, Eric G Pamer
Jan 18, 2019·Clinical Microbiology Reviews·Fernando L Gordillo Altamirano, Jeremy J Barr
Jul 10, 2019·Frontiers in Microbiology·Marcela LeónRoberto Bastías
Apr 20, 2019·Viruses·Alan Fauconnier
Oct 14, 2020·PLoS Biology·Vivek K MutalikAdam P Arkin
Feb 16, 2021·Frontiers in Microbiology·Samuel PenzinerDavid T Pride
Jul 3, 2017·Journal of Theoretical Biology·Chung Yin Joey Leung, Joshua S Weitz
Jul 14, 2021·Evolution, Medicine, and Public Health·James GurneyMichael E Hochberg

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