PMID: 9185145Jul 1, 1997Paper

Bacteriophages of Streptococcus pneumoniae: a molecular approach

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
P GarcíaR López

Abstract

We have characterized four families of pneumococcal phages with remarkable morphologic and physiological differences. Dp-1 and Cp-1 are lytic phages, whereas HB-3 and EJ-1 are temperate phages. Interestingly, Cp-1 and HB-3 have a terminal protein covalently linked to the 5' ends of their lineal DNAs. In the case of Dp-1, we have found that the choline residues of the teichoic acid were essential components of the phage receptors. We have also developed a transfection system using mature DNAs from Dp-4 and Cp-1. In the later case, the transfecting activity of the DNA was destroyed by treatment with proteolytic enzymes, a feature also shared by the genomes of several small Bacillus phages. DNA replication was investigated in the case of Dp-4 and Cp-1 phages. The terminal protein linked to Cp-1 DNA plays a key role in the peculiar mechanism of DNA replication that has been coined as protein-priming. Recently, the linear 19,345-bp double-stranded DNA of Cp-1 has been completely sequenced, several of its gene products have been analyzed, and a complete transcriptional map has been ellaborated. Most of the pneumococcal lysins exhibit an absolute dependence of the presence of choline in the cell wall substrate for activity, and phage ...Continue Reading

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Citations

Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mario MencíaMargarita Salas
Jun 29, 2002·Journal of Clinical Microbiology·Virginia ObregónJosé L García
Oct 27, 2006·Journal of Molecular Biology·Rubén M BueyJ Fernando Díaz
Nov 13, 2004·FEMS Microbiology Reviews·Rubens López, Ernesto García
Oct 6, 2000·Annual Review of Microbiology·I N WangR Young
Mar 17, 2007·Nature Reviews. Microbiology·Julien Royet, Roman Dziarski
Oct 11, 2020·Microorganisms·Geneviève Garriss, Birgitta Henriques-Normark
May 22, 2019·Microbiology Spectrum·Francesco SantoroGianni Pozzi

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