Bacteriophages: potential treatment for bacterial infections

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Donna H Duckworth, Paul A Gulig

Abstract

Bacteriophages (phages) are viruses of bacteria that can kill and lyse the bacteria they infect. After their discovery early in the 20th century, phages were widely used to treat various bacterial diseases in people and animals. After this enthusiastic beginning to phage therapy, problems with inappropriate use and uncontrolled studies and ultimately the development of antibacterials caused a cessation of phage therapy research in the West. However, a few institutions in Eastern Europe continued to study and use phages as therapeutic agents for human infections. The alarming rise in antibacterial resistance among bacteria has led to a review of the Eastern European studies and to the initiation of controlled experiments in animal models. These recent studies have confirmed that phages can be highly effective in treating many different types of bacterial infections. The lethality and specificity of phages for particular bacteria, the ability of phages to replicate within infected animal hosts, and the safety of phages make them efficacious antibacterial agents. Although there are still several hurdles to be overcome, it appears likely that phage therapy will regain a role in both medical and veterinary treatment of infectious di...Continue Reading

References

Oct 1, 1992·Journal of Medical Microbiology·J S Soothill
Jun 1, 1994·Burns : Journal of the International Society for Burn Injuries·J S Soothill
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·C R MerrilS Adhya
Apr 1, 2000·Microbes and Infection·M S Strom, R N Paranjpye
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·A SulakvelidzeJ G Morris

❮ Previous
Next ❯

Citations

Jun 4, 2004·Expert Opinion on Investigational Drugs·Joseph M Patti
Jul 19, 2013·Future Medicinal Chemistry·Margaret A RileyRobert L Dorit
Jan 10, 2017·Frontiers in Microbiology·Patrick BuergerMadeleine J H van Oppen
Nov 21, 2018·BMC Bioinformatics·Diogo Manuel Carvalho LeiteCarlos Peña-Reyes
Jul 27, 2014·Annals of Clinical Microbiology and Antimicrobials·Ahmed Sahib AbdulamirFatimah Abu Bakar
Jul 18, 2014·Scientifica·Stephen T Abedon
Oct 9, 2016·Folia Microbiologica·Sonika SharmaMohan G Vairale
Mar 27, 2019·Viruses·Sandra-Maria WienholdMartin Witzenrath
Aug 24, 2019·Frontiers in Microbiology·Robert CzajkowskiSteven E Lindow
Jun 15, 2005·European Journal of Oral Sciences·Jukka H Meurman
Dec 3, 2013·Acta Microbiologica Et Immunologica Hungarica·József KlemGábor Rákhely
Jan 23, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Weilu ChengYudong Huang
May 3, 2018·Beilstein Journal of Nanotechnology·Jaison JeevanandamMichael K Danquah
Oct 3, 2018·Surgical Infections·Jennifer E BakerMichael J Edwards
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Ryohei WatanabeKeizo Yamaguchi
May 2, 2014·World Journal of Microbiology & Biotechnology·Sabah A A Jassim, Richard G Limoges
Dec 7, 2011·Physical Chemistry Chemical Physics : PCCP·Antonio SiberRudolf Podgornik
Jun 14, 2012·Canadian Journal of Microbiology·Yan D NiuTim A McAllister
Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunming LiLigang Yin
May 25, 2021·Frontiers in Pharmacology·Vijay Singh Gondil, Sanjay Chhibber
Jun 11, 2021·BMC Musculoskeletal Disorders·Jian Wang, Liucai Wang
Jan 21, 2006·International Journal of Medical Microbiology : IJMM·Mikael Skurnik, Eckhard Strauch
Oct 2, 2007·Journal of Theoretical Biology·David T Kysela, Paul E Turner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Related Papers

Current Opinion in Investigational Drugs
Andrzej GórskiGrace Filby
British Journal of Clinical Pharmacology
Begoña HerasJennifer L Martin
The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale
Andrew M Kropinski
Archivum Immunologiae Et Therapiae Experimentalis
Jameel M Inal
© 2022 Meta ULC. All rights reserved