Bacteriophages: what role may they play in life after spinal cord injury?

Spinal Cord
Lorenz LeitnerThomas M Kessler

Abstract

Bacterial infections are the leading cause of death in people with a spinal cord injury (SCI). Bacteriophages (phages) are viruses that solely infect and kill bacteria. The idea of using phages to treat bacterial infections, i.e., phage therapy, is very promising and potentially allows a more specific and personalized treatment of bacterial infections than antibiotics. While multi-drug resistant infections affect individuals from the general population, alternative therapeutic options are especially warranted in high-risk populations, such as individuals with SCI. However, more clinical data must be collected before phage therapy can be implemented in clinical practice, with numerous possible, subsequent applications.

References

Oct 6, 2001·The Journal of Spinal Cord Medicine·K B WaitesS A Moser
Nov 10, 2015·Nature Reviews. Microbiology·George P C Salmond, Peter C Fineran
May 6, 2016·Frontiers in Microbiology·Wilbert SybesmaThomas M Kessler
Jun 7, 2017·Critical Care : the Official Journal of the Critical Care Forum·Serge JennesJean-Paul Pirnay
Nov 17, 2019·European Urology Focus·Lorenz LeitnerJochen Klumpp

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Citations

Aug 13, 2021·Spinal Cord·Jörg Krebs

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